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RAI1

Official Full Name

retinoic acid induced 1
Overview

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients.
Synonyms

RAI1; retinoic acid induced 1; SMCR, Smith Magenis syndrome chromosome region; retinoic acid-induced protein 1; DKFZP434A139; KIAA1820; MGC12824; SMS; Smith-Magenis syndrome chromosome region; SMCR;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAI1-49H	Recombinant Human RAI1, GST-tagged	Wheat Germ	GST		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAI1 Related Articles

RAI1 involved in several pathways and played different roles in them. We selected most pathways RAI1 participated on our site, such as Circadian Clock, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Circadian Clock	CARM1;CSNK1E;HELZ2;CRY2;RAI1;DBP;NAMPT;CRY1;CPT1A

RAI1 has several biochemical functions, for example, enhancer binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAI1 itself. We selected most functions RAI1 had, and list some proteins which have the same functions with RAI1. You can find most of the proteins on our site.

Function	Related Protein
enhancer binding	TCF3;RAI1;MESP1;SP1;TIPARP;SMAD2;SMAD3;ELL3;AHR
protein binding	UBE2D3;MRPL11;CRYAA;GRK5;NUB1;ROCK1;SMARCD1;KAT2B;HYAL2
transcription factor activity, sequence-specific DNA binding	SOX1;TBX4;ENO1;FOXI1;SOX5;ZFP82;ZNF621;RARG;ZNF354B
zinc ion binding	ADAM20;ADAM10B;IFIH1;CHURC1;ZNF207;TRAF5;MAN2B2;TRIM74;TET1

RAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAI1.

PIN1; RPS6KA5; TTR; GADD45A; CDKN1A; CASP2; GSK3B; MAPK8IP2; ypwA; TESC; CDK2AP1; Cbx1; PYHIN1; Mta1; HMG20A; DAXX; TCF20

Huang, HQ; Saravia, J; et al. Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants. IMMUNOLOGY AND CELL BIOLOGY 93:126-135(2015).

Chen, QY; Ross, AC; et al. All-trans-retinoic acid and CD38 ligation differentially regulate CD1d expression and alpha-galactosylceramide-induced immune responses. IMMUNOBIOLOGY 220:32-41(2015).