RASGRP3

  • Official Full Name

    RAS guanyl releasing protein 3 (calcium and DAG-regulated)

  • Overview

    Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).

  • Synonyms

    RASGRP3;RAS guanyl releasing protein 3 (calcium and DAG-regulated);ras guanyl-releasing protein 3;GRP3;KIAA0846;guanine nucleotide exchange factor for Rap1;calcium and DAG-regulated guanine nucleotide exchange factor III

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RASGRP3-2190H Recombinant Human RASGRP3, GST-tagged E.coli Human GST C-term-349aa
RASGRP3-1543C Recombinant Chicken RASGRP3 Mammalian Cells Chicken His
RASGRP3-3794R Recombinant Rhesus monkey RASGRP3 Protein, His-tagged Mammalian Cells Rhesus macaque His
RASGRP3-405H Recombinant Human RASGRP3 Protein, GST/His-tagged E.coli Human GST&His
RASGRP3-6184Z Recombinant Zebrafish RASGRP3 Mammalian Cells Zebrafish His
RASGRP3-2504HCL Recombinant Human RASGRP3 293 Cell Lysate HEK293 Human Non
RASGRP3-3611R Recombinant Rhesus Macaque RASGRP3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
RASGRP3-3611R-B Recombinant Rhesus Macaque RASGRP3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Rasgrp3-5391M Recombinant Mouse Rasgrp3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    RASGRP3 involved in several pathways and played different roles in them. We selected most pathways RASGRP3 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer PLCG1,TGFB3,GNG12,TRP53,BDKRB2,RXRG,RARA,LPAR4,DAPK3,STK36
    Rap signaling pathway Itgam&Itgb2,GRIN2B,NGFR,PRKCA,PRKCZ,PGF,PDGFC,ITGAM,FGFR1,PRKD2
    Ras signaling pathway PLCG1,PRKACG,GNG8,RAB5B,KIT,PDGFRB,KSR1,PLA2G2F,PAK6,FGF11
    MAPK signaling pathway TNFRSF1A,PRKCA,MAP2K6,FGF1A,PRKACAB,ZAK,MAPKAPK5,CACNA2D1,HRAS,PPM1B
    B Cell Receptor Signaling Pathway LYN,LCP2A,MAP2K2,FOS,cgr2b,PLEKHA1,INPP5D,CSK,BANK1,PIK3AP1

    Protein Function

    RASGRP3 has several biochemical functions, for example, GTPase activator activity,Ras GTPase binding,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP3 itself. We selected most functions RASGRP3 had, and list some proteins which have the same functions with RASGRP3. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity DOCK4,ARHGEF7B,RASGEF1BB,PLCE1,SH2D3C,PRSS56,DOCK11,DOCK7,BCAR3,FFAR1
    GTPase activator activity TBC1D16,TBC1D2,AGFG1,DOCK2,AXIN2,AGAP2,TBC1D3C,LLGL1,TBC1D5,RGS5
    kinase binding CHP,CDC37,PFKL,UBQLN1,PIP5K1A,PTPN22,CTNNB1,DLG4,DLG3,BCL10
    protein binding KIR2DL1,DCAF11,CTNNB1,TBC1D20,PIR,SNW1,F11R,LRPPRC,FRMD6,CLEC7A
    Ras guanyl-nucleotide exchange factor activity RASGRP4,RGL2,RASGRP1,KNDC1,ADRB1,RASGEF1B,RAPGEF5,RASGEF1BB,RASGEF1A,RAB3A
    Ras GTPase binding MLLT4,CIB1,RGL3,RAP1A,MAP2K1,RAPGEF4,RAP1GAP,RIN1,SH3BP4,RAPGEF6
    signal transducer activity MRGPRB4,PLCG2,OLFR50,MALT1,OLFR486,ADRA2DB,OPN1SW1,VAPA,ERG,OLFR151
    calcium ion binding SPOCK3,CPNE6,PADI2,CRB2B,PCDHGA4,ANXA3,RAB11FIP4,GUCA1A,MGMT,CHP1
    diacylglycerol binding TRPC2,RASGRP1,RASGRP2,RASGRP4,UNC13A,UNC13C,UNC13B,CDIPT

    Interacting Protein

    RASGRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP3.

    DYNLL2;YWHAQ;SULT1C2;uxuA

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