Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

RASGRP3

Official Full Name

RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Overview

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).
Synonyms

RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated); ras guanyl-releasing protein 3; GRP3; KIAA0846; guanine nucleotide exchange factor for Rap1; calcium and DAG-regulated guanine nucleotide exchange factor III;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
GST|His
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RASGRP3-2190H	Recombinant Human RASGRP3, GST-tagged	E.coli	GST	C-term-349aa	$319 / 25ug
Human	RASGRP3-405H	Recombinant Human RASGRP3 Protein, GST/His-tagged	E.coli	GST/His		Inquiry
Human	RASGRP3-2504HCL	Recombinant Human RASGRP3 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Rasgrp3-5391M	Recombinant Mouse Rasgrp3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	RASGRP3-3794R	Recombinant Rhesus monkey RASGRP3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	RASGRP3-3611R-B	Recombinant Rhesus Macaque RASGRP3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	RASGRP3-3611R	Recombinant Rhesus Macaque RASGRP3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	RASGRP3-6184Z	Recombinant Zebrafish RASGRP3	Mammalian Cell	His		Inquiry
Chicken	RASGRP3-1543C	Recombinant Chicken RASGRP3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RASGRP3 involved in several pathways and played different roles in them. We selected most pathways RASGRP3 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	GADD45BB;LRRK2;FGF21;C11orf52;ARRB2B;SOS1;FLNC;CACNA1D;Fgf15
Ras signaling pathway	PLCG1;FGF10;FGF21;ARF6;FGF16;HGF;NFKB1;NRAS;PLA2G2D
Rap signaling pathway	VEGFA;PFN3;ACTB;TEK;GNAQ;CDH1;FGFR3;PLCB2;RASGRP3
B cell receptor signaling pathway	DOK1B;DUSP6;ARPC2;RAC1;NFATC3;PIK3CA;MAP2K1;ARPC5;PIK3R5
Pathways in cancer	PIK3CA;FLT3LG;HRAS;PIK3CG;LAMB1;SMO;RAC2;SPI1;RAD51

RASGRP3 has several biochemical functions, for example, GTPase activator activity, Ras GTPase binding, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP3 itself. We selected most functions RASGRP3 had, and list some proteins which have the same functions with RASGRP3. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	RGS19;NCKAP1L;TBC1D30;ADAP2;STARD8;RIN3;ARAP2;ABR;AGFG1B
Ras GTPase binding	RIN1;RASGRP3;RAP1GAP;MLLT4;MAPKAP1;RGL3;PLCE1;RAPGEF6;RAPGEF4
Ras guanyl-nucleotide exchange factor activity	RASGEF1B;RAPGEF4;RASGRP4;RASGEF1A;RAPGEF5;RASGEF1BA;RGL2;KNDC1;RASGRP3
calcium ion binding	SPTA1;PCDH1G22;THBS4B;DUOX2;CAPN11;SLC24A5;SCUBE1;DLL1;SGCA
diacylglycerol binding	CDIPT;TRPC2;UNC13C;RASGRP2;UNC13A;RASGRP4;RASGRP3;UNC13B;RASGRP1
guanyl-nucleotide exchange factor activity	ARHGEF7A;DOCK1;DOCK7;DOCK6;SPATA13;PCP2;RASGRP3;DOCK4B;PREX1
kinase binding	DUSP12;JAKMIP3;DLG4;TRADD;CHP;TNFAIP3;DLG1;PIP5K1A;ATF5
protein binding	GORASP1;NEK11;LRRC75A-AS1;GAPDHS;RNF216;DNAJC10;TAF1D;C4orf46;DCAF8
signal transducer activity	AKAP13;TRHRB;TAAR14A;VALOPB;EMR4;PLCH2;TAAR12J;MRGPRA5;TAAR2

RASGRP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP3.

DYNLL2; YWHAQ; SULT1C2; uxuA