RASGRP4

  • Official Full Name

    RAS guanyl releasing protein 4

  • Overview

    The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RASGRP4;RAS guanyl releasing protein 4;RAS guanyl-releasing protein 4;guanyl nucleotide releasing protein 4

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RASGRP4-2191H Recombinant Human RASGRP4, GST-tagged E.coli Human GST 1-168aa
RASGRP4-13955M Recombinant Mouse RASGRP4 Protein Mammalian Cells Mouse His
RASGRP4-3983Z Recombinant Zebrafish RASGRP4 Mammalian Cells Zebrafish His
RASGRP4-4938R Recombinant Rat RASGRP4 Protein Mammalian Cells Rat His
RASGRP4-1477HCL Recombinant Human RASGRP4 cell lysate Human Non
RASGRP4-4597R Recombinant Rat RASGRP4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
RASGRP4-4597R-B Recombinant Rat RASGRP4 Protein Pre-coupled Magnetic Beads HEK293 Rat
RASGRP4-7439M Recombinant Mouse RASGRP4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RASGRP4-7439M-B Recombinant Mouse RASGRP4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RASGRP4 involved in several pathways and played different roles in them. We selected most pathways RASGRP4 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downstream signal transduction AGO1,JAK1,SPTBN1,FGF20A,SPTBN2,IL17RD,GRB7,FGFR1B,SPTB,THEM4
    DAP12 interactions PTPRA,DUSP9,PHB,ADRBK1,FGFR1B,SPRED2,NEFLB,FRS2A,TRAT1,DUSP7
    Cytokine Signaling in Immune system IL17RD,PRLRB,FGF8B,GBP6,IFI30,IFITM2,IFITM3,IFIT12,MARK3,SPTBN2
    DAP12 signaling CSF2RA,PEA15,GRAP2A,SPRED3,FRS2A,HBEGF,FGF8B,KBTBD7,DUSP6,FRS2
    Axon guidance PAK3,MYL12B,MYL12A,TRPC3,EPHA8,DUSP2,SEMA3E,RHOGA,DLG3,COL9A1
    Downstream signaling of activated FGFR1 SPRED3,MARK3,AGO2,PEA15,IL17RD,RASGEF1A,SPTA1,DAB2IPB,SPRED2,KBTBD7
    Developmental Biology ARPC5,EFNB2,NRG3,FGF8B,KIF4A,DUSP2,DPYSL5A,FRS2B,SPRED3,CLTA
    ARMS-mediated activation NRG2A,FGF20A,CSF2RB,SPTBN1,PEA15,NEFLB,PEA15A,WDR83,PSMD9,SPTB

    Protein Function

    RASGRP4 has several biochemical functions, for example, GTP-dependent protein binding,Ras guanyl-nucleotide exchange factor activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP4 itself. We selected most functions RASGRP4 had, and list some proteins which have the same functions with RASGRP4. You can find most of the proteins on our site.

    Function Related Protein
    Ras guanyl-nucleotide exchange factor activity RASGRP1,RASGEF1B,ADRB1,SOS1,RGL2,RAPGEF4,KNDC1,RASGEF1A,RAPGEF5,RAB3A
    GTP-dependent protein binding RAPGEF6,RAB32,AP1G1,PARD6A,ARFIP2,GCH1,RAPGEF5,PPIAL4A,GCHFR,RAB5B
    diacylglycerol binding RASGRP3,UNC13C,UNC13A,TRPC2,RASGRP2,UNC13B,CDIPT,RASGRP1
    calcium ion binding DSG1A,TPM4,MICU1,MYL3,KCNIP3,PADI3,TNNC1A,EHD2B,CABP2A,SNCB

    Interacting Protein

    RASGRP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP4.

    RAP1A

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