HHAT

Official Full Name

hedgehog acyltransferase
Overview

Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
Synonyms

HHAT; hedgehog acyltransferase; protein-cysteine N-palmitoyltransferase HHAT; FLJ10724; GUP2; MART 2; MART2; rasp; sit; ski; Skn; 2810432O22Rik; AI462858; FLJ34867; AC115917.1; HHAT_HUMAN; MART-2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; OTTHUMP00000034608; OTTHUMP00000034611;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	HHAT-255H	Recombinant Human HHAT Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Mouse	HHAT-7609M	Recombinant Mouse HHAT Protein	Mammalian Cell	His	Inquiry
Mouse	HHAT-4149M	Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Hhat-3389M	Recombinant Mouse Hhat Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	HHAT-4149M-B	Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	HHAT-6488Z	Recombinant Zebrafish HHAT	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis, Signal Transduction, Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog ligand biogenesis	DISP2;OS9;NOTUM;SCUBE2;GPC5A;NOTUM1A;HHAT;DERL2
Signal Transduction	ADM2;GPR31B;RLN3;OXGR1A.2;ROPN1;CCBP2;GPR18;INTU;RGS17
Signaling by Hedgehog	BOC;NOTUM;SPOP;DZIP1;SCUBE2;EVC;NOTUM1A;RPGRIP1L;INTU

HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity, 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity, 2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

Function	Related Protein
2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity	Acnat1;CML2;MBOAT4;NAT14;ACNAT2;DGAT2L6;HHAT;MBOAT7;MBOAT1
2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity	LPCAT3;CML2;MBOAT1;CML5;DGAT2L6;NAT14;ACNAT2;MBOAT4;HHAT
2-methylhexanoyl-CoA C-acetyltransferase activity	CML5;MBOAT4;HHAT;Acnat1;CML2;MBOAT1;DGAT2L6;MBOAT7;NAT14
3-hydroxybutyryl-CoA thiolase activity	LPCAT3;MBOAT1;HHAT;MBOAT4;DGAT2L6;NAT14;Acnat1;MBOAT7;CML5
3-ketopimelyl-CoA thiolase activity	LPCAT3;MBOAT4;MBOAT1;NAT14;HHAT;ACNAT2;MBOAT7;DGAT2L6;Acnat1
C-acyltransferase activity	ACNAT2;NAT14;DGAT2L6;MBOAT1;HHAT;LPCAT3;MBOAT4;CML5;MBOAT7
C-palmitoyltransferase activity	CML5;DGAT2L6;NAT14;ACNAT2;LPCAT3;MBOAT7;CML2;Acnat1;HHAT
GTP binding	TUBA3C;RRAD;GIMAP2;INSR;GIMAP4;SRP54B;GIMAP3;MFHAS1;RAC2
L-2-aminoadipate N-acetyltransferase activity	MBOAT1;CML2;NAT14;HHAT;MBOAT4;DGAT2L6;MBOAT7;ACNAT2;LPCAT3
N-acetyltransferase activity	NAT6;NAA10;SAT2B;LPCAT3;SAT1A.2;NAT10;SMARCE1;SAT1B;Acnat1
N-acyltransferase activity	CML5;Acnat1;MBOAT7;LPCAT3;MBOAT1;MBOAT4;NAT14;ACNAT2;HRASLS5
N-palmitoyltransferase activity	DGAT2L6;HHAT;CML5;MBOAT1;Acnat1;ACNAT2;LPCAT3;NAT14;CML2
N-succinyltransferase activity	MBOAT7;LPCAT3;DGAT2L6;MBOAT4;HHAT;Acnat1;ACNAT2;NAT14;CML5
O-acetyltransferase activity	MBOAT7;CML2;MBOAT4;CML5;MBOAT1;Acnat1;DGAT2L6;ACNAT2;NAT14
O-acyltransferase activity	DGAT1A;MBOAT7;Acnat1;CML5;MBOAT4;LPCAT3;MBOAT1;ACNAT2;DGAT1B
O-octanoyltransferase activity	DGAT2L6;HHAT;MBOAT4;MBOAT7;NAT14;MBOAT1;CML5;LPCAT3;CML2
O-palmitoyltransferase activity	MBOAT7;CML5;ACNAT2;Acnat1;MBOAT1;MBOAT4;HHAT;LPCAT3;NAT14
O-sinapoyltransferase activity	NAT14;MBOAT4;DGAT2L6;LPCAT3;HHAT;ACNAT2;CML2;MBOAT7;Acnat1
O-succinyltransferase activity	DGAT2L6;ACNAT2;HHAT;MBOAT4;NAT14;Acnat1;LPCAT3;CML2;MBOAT1
Ras palmitoyltransferase activity	MBOAT7;MBOAT4;Acnat1;LPCAT3;CML5;HHAT;CML2;ACNAT2;NAT14
S-acetyltransferase activity	MBOAT1;Acnat1;MBOAT4;DGAT2L6;CML5;NAT14;CML2;HHAT;ACNAT2
S-acyltransferase activity	MBOAT7;LPCAT3;Acnat1;MBOAT4;CML2;MBOAT1;ACNAT2;HHAT;NAT14
S-malonyltransferase activity	CML5;MBOAT1;NAT14;ACNAT2;Acnat1;MBOAT7;DGAT2L6;HHAT;MBOAT4
S-succinyltransferase activity	LPCAT3;DGAT2L6;HHAT;Acnat1;MBOAT1;CML5;CML2;NAT14;ACNAT2
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity	NAT14;MBOAT4;MBOAT7;CML2;LPCAT3;Acnat1;CML5;HHAT;MBOAT1
acetyl-CoA:L-lysine N6-acetyltransferase	MBOAT1;CML2;HHAT;LPCAT3;CML5;Acnat1;DGAT2L6;ACNAT2;NAT14
acetyltransferase activity	KAT5;LPCAT3;Acnat1;KAT8;CML2;CML5;AANAT1;KAT6B;MBOAT1
acyl-CoA N-acyltransferase activity	ACNAT2;MBOAT4;DGAT2L6;NAT14;MBOAT7;CML5;Acnat1;MBOAT1;LPCAT3
acylglycerol O-acyltransferase activity	LPCAT3;ACNAT2;Acnat1;MBOAT1;HHAT;MBOAT7;CML5;DGAT2L6;NAT14
azetidine-2-carboxylic acid acetyltransferase activity	Acnat1;MBOAT7;CML2;LPCAT3;MBOAT4;MBOAT1;CML5;DGAT2L6;NAT14
benzoyl acetate-CoA thiolase activity	HHAT;MBOAT4;DGAT2L6;CML2;MBOAT1;NAT14;MBOAT7;LPCAT3;CML5
butyryl-CoA 2-C-propionyltransferase activity	CML5;Acnat1;MBOAT1;DGAT2L6;CML2;NAT14;HHAT;MBOAT7;MBOAT4
carnitine O-acyltransferase activity	CML5;ACNAT2;CML2;HHAT;NAT14;MBOAT1;LPCAT3;Acnat1;DGAT2L6
dihydrolipoamide S-acyltransferase activity	HHAT;MBOAT1;ACNAT2;CML5;CML2;Acnat1;MBOAT4;DGAT2L6;LPCAT3
dihydrolipoamide branched chain acyltransferase activity	HHAT;CML2;NAT14;MBOAT1;CML5;DGAT2L6;ACNAT2;LPCAT3;MBOAT7
ergosterol O-acyltransferase activity	CML2;Acnat1;NAT14;MBOAT7;LPCAT3;CML5;HHAT;DGAT2L6;ACNAT2
glucosaminyl-phosphotidylinositol O-acyltransferase activity	MBOAT4;HHAT;DGAT2L6;NAT14;ACNAT2;MBOAT7;LPCAT3;Acnat1;CML5
keto acid formate lyase activity	MBOAT7;DGAT2L6;MBOAT1;MBOAT4;LPCAT3;CML2;CML5;NAT14;Acnat1
lanosterol O-acyltransferase activity	MBOAT7;HHAT;MBOAT1;LPCAT3;DGAT2L6;ACNAT2;CML5;MBOAT4;Acnat1
malonyltransferase activity	LPCAT3;CML5;NAT14;MBOAT4;MBOAT7;ACNAT2;Acnat1;CML2;DGAT2L6
myristoyltransferase activity	Acnat1;CML5;HHAT;MBOAT7;MBOAT4;CML2;MBOAT1;DGAT2L6;NAT14
naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity	MBOAT4;MBOAT7;MBOAT1;HHAT;DGAT2L6;CML2;Acnat1;NAT14;CML5
nucleotide binding	TOR1L3;RAB18B;NT5C2;UBE2G1B;RHOGA;DDX19;EWSR1;MYHZ2;GNA15.4
octanoyltransferase activity	LPCAT3;MBOAT1;MBOAT4;ACNAT2;CML2;NAT14;DGAT2L6;CML5;MBOAT7
palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity	Acnat1;DGAT2L6;NAT14;CML5;MBOAT7;HHAT;MBOAT1;ACNAT2;LPCAT3
palmitoyltransferase activity	ZDHHC15;CML2;ZDHHC14;ZDHHC17;CML5;ZDHHC5;ACNAT2;ZDHHC7;ZDHHC1
peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	MBOAT7;ACNAT2;NAT14;DGAT2L6;MBOAT1;CML5;MBOAT4;LPCAT3;NAA50
peptidyl-lysine N6-myristoyltransferase activity	Acnat1;DGAT2L6;NAT14;ACNAT2;MBOAT4;LPCAT3;HHAT;CML5;CML2
peptidyl-lysine N6-palmitoyltransferase activity	MBOAT1;LPCAT3;CML5;CML2;MBOAT4;ACNAT2;DGAT2L6;MBOAT7;HHAT
protein-cysteine S-acyltransferase activity	NAT14;MBOAT1;LPCAT3;CML5;HHAT;Acnat1;MBOAT4;MBOAT7;DGAT2L6
protein-cysteine S-myristoyltransferase activity	MBOAT1;DGAT2L6;MBOAT7;MBOAT4;CML5;HHAT;Acnat1;ACNAT2;LPCAT3
serine O-acyltransferase activity	HHAT;NAT14;DGAT2L6;ACNAT2;MBOAT1;Acnat1;LPCAT3;CML5;MBOAT4
sinapoyltransferase activity	HHAT;MBOAT7;LPCAT3;CML5;MBOAT4;MBOAT1;CML2;DGAT2L6;Acnat1
sterol O-acyltransferase activity	CML5;HHAT;NAT14;DGAT2L6;LPCAT3;MBOAT7;CML2;SOAT1;Acnat1
succinyltransferase activity	ACNAT2;CML2;NAT14;Acnat1;MBOAT7;HHAT;LPCAT3;MBOAT1;MBOAT4
transferase activity	FUT9D;OAS1B;EOGT;TRIO;B3GNT2B;UGT2A5;NMT1B;UGT2B3;CMTR2
transferase activity, transferring acyl groups	ZDHHC16;AANAT;KEG1;LIPT2;TMEM68;ZDHHC6;AGPAT9L;CDYL;ZDHHC15A

HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.