RBBP5

  • Official Full Name

    retinoblastoma binding protein 5

  • Overview

    This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

  • Synonyms

    RBBP5;retinoblastoma binding protein 5;RBQ3;SWD1;retinoblastoma-binding protein 5;RBBP-5;retinoblastoma-binding protein RBQ-3;SWD1, Set1c WD40 repeat protein, homolog

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • SUMO
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RBBP5-2199H Recombinant Human RBBP5, GST-tagged E.coli Human GST N-term-327aa
RBBP5-025H Active Recombinant Human RBBP5 Protein, SUMO-tagged E.coli Human SUMO 2-538
RBBP5-082H Active Recombinant Human RBBP5 Protein E.coli Human
RBBP5-10585Z Recombinant Zebrafish RBBP5 Mammalian Cells Zebrafish His
RBBP5-13977M Recombinant Mouse RBBP5 Protein Mammalian Cells Mouse His
RBBP5-2603C Recombinant Chicken RBBP5 Mammalian Cells Chicken His
RBBP5-28182TH Recombinant Human RBBP5, His-tagged E.coli Human His 359-538 a.a.
RBBP5-1479HCL Recombinant Human RBBP5 cell lysate Human Non
RBBP5-7458M Recombinant Mouse RBBP5 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RBBP5-7458M-B Recombinant Mouse RBBP5 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RBBP5 involved in several pathways and played different roles in them. We selected most pathways RBBP5 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Deactivation of the beta-catenin transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Wnt PYGO2,C,LGR4,CBY1,USP34,PYGO1,LGR5,RSPO3,WIF1,LEO1
    Chromatin modifying enzymes MORF4L1,ATXN7L3,SMARCC2,SAP18,PHF8,KDM6B,PHF17,KAT6A,JADE1,MTA3
    TCF dependent signaling in response to WNT KREMEN1,PYGO1,RSPO4,LGR6,RNF146,SOX32,LEO1,RNF43,SOX9A,SOX7
    Deactivation of the beta-catenin transactivating complex SOX7,TLE1,PYGO2,ASH2L,SOX4A,TLE4,BCL9,SOX32,SOX6,BCL9L
    Formation of the beta-catenin:TCF transactivating complex PYGO1,TLE1,TLE3B,SMARCA4,ASH2L,BCL9L,LEO1,BCL9,TLE3,TLE4
    Signal Transduction PDK2,BCO2L,ARHGAP8,ANXA1C,IQCE,MKS1,RHOT1A,VIP2,TNKS2,THBS3B
    Chromatin organization KDM1A,KAT7,JHDM1D,TADA2A,CHD4A,SMARCC1,MTA3,TAF6L,PBRM1,KDM7AB
    PKMTs methylate histone lysines SUZ12A,SMYD2,AEBP2,DPY30,SUZ12B,SMYD2A,ATF7IP,EED,SUZ12,EHMT2

    Protein Function

    RBBP5 has several biochemical functions, for example, contributes_to histone methyltransferase activity (H3-K4 specific),methylated histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP5 itself. We selected most functions RBBP5 had, and list some proteins which have the same functions with RBBP5. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to histone methyltransferase activity (H3-K4 specific) CXXC1,ASH2L,DPY30,DYDC1,DYDC2
    methylated histone binding KDM4A,ING3,MPHOSPH8,PHF19,WDR92,PHF1,CDYL2,MTF2,LRWD1,CHD1
    protein binding FBXL14,THBS4,MTSS1,PRMT6,AARSD1,BMI1,PXMP2,MRPS23,ERBB3,NFE2L3
    transcription regulatory region DNA binding TFEB,DDIT3,TOMM20A,ZNF649,SOX2,KLF15,OVOL2,CTCFL,KLF11,TRP53

    Interacting Protein

    RBBP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP5.

    ASH2L;KMT2A

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