RCC1
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Official Full Name
regulator of chromosome condensation 1 -
Overview
The Regulator of Chromosome Condensation 1 (RCC1) is a critical cell cycle regulator. This protein is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds to chromatin and interacts with Ran, a nuclear GTP-binding protein. This complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP. -
Synonyms
RCC1;regulator of chromosome condensation 1;CHC1, chromosome condensation 1;regulator of chromosome condensation;cell cycle regulatory protein;SNHG3-RCC1 readthrough transcript;guanine nucleotide-releasing protein;CHC1;RCC1-I;SNHG3-RCC1;rcc1-a;CHC 1;Chromosome condensation 1;Chromosome condensation protein 1;Guanine nucleotide releasing protein;HERC2;Ran GEF;RanGEF;RCC 1;RCC1 I;RCC1_HUMAN;SHEP1;SNHG3 RCC1;SNHG3 RCC1 readthrough transcript;xrcc1;chc1-a
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E. coli
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- Non
- His
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
RCC1 involved in several pathways and played different roles in them. We selected most pathways RCC1 participated on our site, such as Disease,HIV Infection,HIV Life Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Infectious disease | KPNA3,SYT2,APOBEC3G,KPNA5,ANTXR2,NMT1,DOCK2,EEF2,AP1S1,AP1M2 |
| Late Phase of HIV Life Cycle | TAF1L,PDCD6IP,NMT2 |
| HIV Infection | TAF1L,AP1G1,PSIP1,AP1M2,CHMP4C,AP1B1,VPS37A,PACS1,PPIAL4A,PDCD6IP |
| Host Interactions of HIV factors | PACS1,AP1B1,AP1G1,APOBEC3G,PPIAL4A,PSIP1,AP1S1,DOCK2,AP1M2 |
| Disease | PACS1,AP2A2,RBP1,CFTR,NA,GPC5,PRELP,OPN1LW,TRAT1,RNF43 |
| HIV Life Cycle | VPS37A,PSTPIP2,SSRP1,ELL,PSIP1,CHMP4B,PDCD6IP,NMT2,CHMP4C,TAF1L |
Protein Function
RCC1 has several biochemical functions, for example, Ran guanyl-nucleotide exchange factor activity,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCC1 itself. We selected most functions RCC1 had, and list some proteins which have the same functions with RCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | TRIM24,KDM1A,BRD4,KDM5A,NCAPD2,TSHZ3,CHAF1B,GLI1,EGFR,HMGB1A |
| nucleosomal DNA binding | H2AFZ,H3F3C,H3F3A,HMGN3,H1FOO,HMGN5,HMGN4,H2AFY,HMGN2,HMGA2 |
| protein binding | BCL2A1,KEL,CLCNKB,MASP1,FRMD5,CCDC130,SHISA5,ARHGEF2,ASPH,CDK4 |
| Ran guanyl-nucleotide exchange factor activity | ALS2,RCBTB2,SERGEF,RANGRF,RANBP10 |
| histone binding | ASF1B,ATAD2,SART3,APBB1,UHRF1,DNAJC2,HINFP,HIST3H3,CD1d1,NCAPD2 |
Interacting Protein
RCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCC1.
RAN;gdp;Ranbp2;VCAM1;RANBP3;CSNK1A1;gtp
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References
- Rozier, L; Guo, YG; et al. The MRN-CtIP Pathway Is Required for Metaphase Chromosome Alignment. MOLECULAR CELL 49:1097-1107(2013).
- Ohgami, H; Hiyoshi, M; et al. Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis. DEVELOPMENT GROWTH & DIFFERENTIATION 54:660-671(2012).
