RCC2

  • Official Full Name

    regulator of chromosome condensation 2
  • Overview

    RCC2/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors. RCC2/TD-60 is associated with the chromosome passenger complex (CPC), which also consists of aurora B kinase, borealin, INCENP (inne
  • Synonyms

    RCC2;regulator of chromosome condensation 2;protein RCC2;TD 60;RCC1-like protein TD-60;telophase disk protein of 60 kDa;TD-60;KIAA1470;DKFZp762N0610
Cat.# Product name Source (Host) Species Tag Protein Length Price
RCC2-2230H Recombinant Human RCC2, His-tagged E.coli Human His 168-522aa
RCC2-12390Z Recombinant Zebrafish RCC2 Mammalian Cells Zebrafish His
RCC2-14032M Recombinant Mouse RCC2 Protein Mammalian Cells Mouse His
RCC2-7496M Recombinant Mouse RCC2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RCC2-7496M-B Recombinant Mouse RCC2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RCC2 involved in several pathways and played different roles in them. We selected most pathways RCC2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle TGFB3,TFDP2,LIN52,SKP1,BUB1B,HDAC1,YWHAQ,ORC4,CDC20,SETB
    Mitotic Metaphase and Anaphase VRK2,ZW10,MIS12,CENPL,RANGAP1B,CCDC99,NSL1,CENPP,NDC80,CENPH
    RHO GTPase Effectors BAIAP2,ACTR2B,ZWINT,WASF3,KLC3,KNTC1,ABI2,WIPF3,CCDC99,LIN7B
    Mitotic Anaphase CENPI,SKA2,LEMD3,WAPAL,NSL1,RANGAP1B,CENPO,NUDC,PDS5B,TMPO
    RHO GTPases Activate Formins SPDL1,NDEL1B,FMNL2,MKL1,PMF1,NUF2,RANGAP1B,CCDC99,RHOC,MKL1B
    Mitotic Prometaphase CENPK,CENPH,NSL1,SGOL2,CENPN,ERCC6L,CCDC99,NCAPD2,CENPP,CLIP1
    M Phase NEK7,LEMD3,ENSAB,CDCA5,ITGB3BP,KNTC1,CTDNEP1,B9D2,INCENP,NCAPD3
    Cell Cycle, Mitotic NDEL1,ARPP19B,BANF1,CDKN1B,H3F3D,CEP164,CENPQ,NDEL1A,FGFR1OP,CDK11B

    Protein Function

    RCC2 has several biochemical functions, for example, Rac GTPase binding,microtubule binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCC2 itself. We selected most functions RCC2 had, and list some proteins which have the same functions with RCC2. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding ARHGAP4A,PAK6,PAK2,NCF2,RAB7A,PAK7,PKN1,ITPKA,HACE1,ARHGEF2
    protein domain specific binding SCN5A,NR0B2,MPP7,HIST2H4,DDC,CASKIN1,ARFIP2,DDX20,ODF1,RAB6A
    small GTPase binding TSC2,FLNA,FGD1,FGD5,FGD6,RNF152,GDI2,PEX5L,FGD4,ABCA1
    protein binding VPS8,BRCA1,LILRB4,RANBP6,RMND5A,BRCC3,SMARCAL1,SLIT2,SNAP23,PTRH2
    protein kinase binding CCNYL1,RPS19,VRK1,WAS,CCNY,YWHAZ,PRC1,IL31RA,SPRED1,BAG5
    poly(A) RNA binding DDX39A,RBM38,NSA2,RPL10,PRRC2A,EIF2S1A,HERC5,SF3A3,PKM,DHX38
    microtubule binding MID2,ZNF207,SGIP1,KIF18B,MAPRE1B,MAPRE3,POLB,KIF26A,PAFAH1B1,CRIPT

    Interacting Protein

    RCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCC2.

    HLA-B;VHL;EIF6;ARF6;ATG5;FTSJ1;TNIK;PRKAB1;TRAF6;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;AIM2;FN1;VCAM1;Nedd1;HDGF

    Resources

    References

    • Grigera, PR; Ma, L; et al. Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. JOURNAL OF PROTEOMICS 75:2153-2159(2012).
    • Yang, F; Camp, DG; et al. Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus. JOURNAL OF CELL SCIENCE 120:4060-4070(2007).
    • Kishimoto, K; Nishizawa, Y; et al. Detailed analysis of rice chitinase gene expression in transgenic cucumber plants showing different levels of disease resistance to gray mold (Botrytis cinerea). PLANT SCIENCE 162:655-662(2002).

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