rln2 Protein, relaxin 2


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Official Full Name relaxin 2
Background Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
Synonyms RLN2; relaxin 2; H2; RLXH2; bA12D24.1.1; bA12D24.1.2; relaxin 2 (H2); prorelaxin H2; relaxin H2; relaxin, ovarian, of pregnancy; Relaxin B chain; Relaxin A chain; OTTHUMP00000021027; OTTHUMP00000196912
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RLN2-172H Recombinant Human Relaxin 2 E.coli N/A
    Human RLN2-173H Recombinant Human Relaxin 2 E.coli N/A
    Human RLN2-220H Recombinant Human RLN2 Protein, His-tagged E.coli His
    Human RLN2-30491TH Recombinant Human RLN2 E.coli N/A
    Human RLN2-7081H Recombinant Human RLN2, His-tagged E.coli His
    Rhesus Macaque RLN2-3904R Recombinant Rhesus monkey RLN2 Protein, His-tagged Mammalian Cell His

    rln2 involved in several pathways and played different roles in them. We selected most pathways rln2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with rln2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors) TAAR1; QRFP; CXCR7B; NMBA; PNOC; CCR3; GPR77; NPFF; GPR132B; GPBAR1
    G alpha (s) signalling events ADCYAP1; DRD5; SCT; RAMP2; RXFP2; PTHRP2; ADRB3; VIP; PDE10A; ADCYAP1R1
    GPCR downstream signaling CYSLTR1; LPAR2A; OPN1LW; FGD4A; GPR65; RHOL; CCL19A.2; CRHR1; GPR17; NPB
    GPCR ligand binding OPN4; NMS; S1PR5B; CCBP2; CCR9; XK; OPN1MW; PRLH; UTS2; UTS2D
    Peptide ligand-binding receptors CCL35.2; NMBB; EDN3; NMB; ZFPM2B; SST; CCL27; PPY; PYY; INSL3
    Relaxin receptors RLN3; RLN2; INSL3; RXFP2; RLN3A; INSL5
    Signal Transduction GPR132; OR4D2; RHOT1A; DCLRE1B; RPE65A; TLE3B; CDC73; TAX1BP1; USP9X; RBP4
    Signaling by GPCR OPN5; RGS14; OPN4.1; ANXA1A; OXGR1; CCRL2; TRH; GHRH; TAS2R16; RLN2

    rln2 has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rln2 itself. We selected most functions rln2 had, and list some proteins which have the same functions with rln2. You can find most of the proteins on our site.

    Function Related Protein
    hormone activity PTH1B; FSD1; UTS2; PRL2C3; METRNL; INS1; POMCA; RLN3A; PRL2; HAMP

    rln2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rln2 here. Most of them are supplied by our site. Hope this information will be useful for your research of rln2.

    Arroyo, JI; Hoffmann, FG; et al. Evolution of the Relaxin/Insulin-Like Gene Family in Anthropoid Primates. GENOME BIOLOGY AND EVOLUTION 6:491-499(2014).
    Rocha, FG; Slavin, TP; et al. Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 209:-(2013).

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