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RNF111

Official Full Name

ring finger protein 111
Overview

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.
Synonyms

RNF111; ring finger protein 111; E3 ubiquitin-protein ligase Arkadia; ARK; Arkadia; DKFZP761D081; FLJ38008; DKFZp313E0731; DKFZp686H1966;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RNF111-2333H	Recombinant Human RNF111, His-tagged	E.coli	His	636-985aa	$319 / 25ug
Human	RNF111-1516HCL	Recombinant Human RNF111 cell lysate		N/A		Inquiry
Human	RNF111-3390H	Recombinant Human RNF111 protein, His-tagged	E.coli	His	Gln3~Ala179	Inquiry
Mouse	RNF111-14285M	Recombinant Mouse RNF111 Protein	Mammalian Cell	His		Inquiry
Mouse	RNF111-7641M	Recombinant Mouse RNF111 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RNF111-7641M-B	Recombinant Mouse RNF111 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RNF111-8357Z	Recombinant Zebrafish RNF111	Mammalian Cell	His		Inquiry
Chicken	RNF111-4474C	Recombinant Chicken RNF111	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RNF111 Related Articles

RNF111 involved in several pathways and played different roles in them. We selected most pathways RNF111 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF111 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	RNF111;UBE2E3;UBE2V1;KIF2A;CD300LF;SH3RF1;ERAP2;DCTN2;LILRB2
Antigen processing: Ubiquitination &amp	UBR1;SPSB4;UBA5;FBXO44;UFL1;TRIM11;RNF25;PJA2;PJA1
Proteasome degradation	UFL1;UBE2U;CMTM2A;RNF19B;RNF34;RNF25;UBR2;RNF6;UBE2L6
Class I MHC mediated antigen processing &amp	RNF138;CD207;ARIH2;RNF4;UBE2V2;RNF6;LTN1;DTX3L;ASB4
presentation	ERAP1;ASB9;TRIM69;HUWE1;WWP1;RNF138;RNF41;B2ML;TRIM39
DNA Repair	RAD9B;ELL;COPS2;POLI;CETN2;FAM175A;TIPIN;PPP4CA;COPS6
Downregulation of SMAD2/3:SMAD4 transcriptional activity	SKI;SKIA;SKIB;TRIM33;RNF111;USP9X;USP9;SKILB;PARP1
Formation of Incision Complex in GG-NER	PARP2;RNF111;DDB1;DDB2;CETN2;USP45;PIAS3;CHD1L
Gene Expression	EEF1D;CLNS1A;PLD6;GPR19;ZNF45;ZNF26;CD2BP2;ZNF773;CHD4A
Generic Transcription Pathway	ESRRGA;CTGF;ZNF621;MED15;MED26;ZNF74;NRBF2B;ZNF221;SKI

RNF111 has several biochemical functions, for example, SMAD binding, SUMO polymer binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF111 itself. We selected most functions RNF111 had, and list some proteins which have the same functions with RNF111. You can find most of the proteins on our site.

Function	Related Protein
SMAD binding	SKIB;ACVR1B;SMAD2;SKIA;AXIN1;TGFBR2;BMP2;SMURF2;COL5A2
SUMO polymer binding	RNF111;RNF4;SIMC1;SOBP;RNF222
ligase activity	RNF146;TRIM39;RNF185;UBR7;NEURL3;ZSWIM2;LTN1;UHRF1;TRIM38
protein binding	DNAJA2;TNNI3K;PDE1B;RBBP7;NEFM;POU5F1;C2orf28;ZNF230;RABIF
ubiquitin protein ligase activity	UBE2T;HECTD2;TOPORS;RNF24;BTRC;PELI1;AKTIP;PARK2;RNF2
zinc ion binding	MUL1;ZNF346;PDLIM3A;SOD3A;TRIM52;RNF175;RFFL;ZSWIM4;AMFR

RNF111 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF111 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF111.

UBE2D1; UBE2D3; UBE2I; KRTAP5-9; CSNK2A1

Jimeno, S; Fernandez-Avila, MJ; et al. Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. NUCLEIC ACIDS RESEARCH 43:987-999(2015).

Sun, HY; Liu, YJ; et al. Multiple Arkadia/RNF111 Structures Coordinate Its Polycomb Body Association and Transcriptional Control. MOLECULAR AND CELLULAR BIOLOGY 34:2981-2995(2014).