RNF111
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Official Full Name
ring finger protein 111 -
Overview
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development. -
Synonyms
RNF111;ring finger protein 111;E3 ubiquitin-protein ligase Arkadia;ARK;Arkadia;DKFZP761D081;FLJ38008;DKFZp313E0731;DKFZp686H1966
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF111-2333H | Recombinant Human RNF111, His-tagged | E.coli | Human | His | 636-985aa | |
| RNF111-14285M | Recombinant Mouse RNF111 Protein | Mammalian Cells | Mouse | His |
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| RNF111-4474C | Recombinant Chicken RNF111 | Mammalian Cells | Chicken | His |
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| RNF111-8357Z | Recombinant Zebrafish RNF111 | Mammalian Cells | Zebrafish | His |
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| RNF111-1516HCL | Recombinant Human RNF111 cell lysate | Human | Non |
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| RNF111-3390H | Recombinant Human RNF111 protein, His-tagged | E.coli | Human | His | Gln3~Ala179 |
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| RNF111-7641M | Recombinant Mouse RNF111 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| RNF111-7641M-B | Recombinant Mouse RNF111 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RNF111 involved in several pathways and played different roles in them. We selected most pathways RNF111 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF111 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | TRIM41,RNF25,ATG7,UBR1,UBA5,TRAF7,MKRN1,ASB11,LRR1,FCGR1B |
| Generic Transcription Pathway | ZNF649,ZNF561,NR1I3,ESRRG,ZNF776,ZNF43,ZNF461,ZNF706,ZNF26,ZNF398 |
| Formation of Incision Complex in GG-NER | CHD1L,PIAS3,PARP2,USP45,DDB1,DDB2,CETN2 |
| Class I MHC mediated antigen processing & | RNF144B,RNF14,ASB4,WSB1,CYBA,ATG7,UBA5,ASB13,FBXO3,UBE2E3 |
| Adaptive Immune System | KLB,LRR1,AKT3,CTSO,RNF6,LRRC41,KIF3B,NA,CTSL1,ACTR1A |
| DNA Repair | USP45,ASCC1,ERCC8,DNA2,ALKBH2,COPS6,APITD1,EME1,ZFP830,TP53BP1 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | SKI,SKILB,USP9,USP9X,SKIB,SKIA,TRIM33,PARP1,SMAD3B |
| Proteasome degradation | UBA5,VPRBP,RNF4,ASB10,KLHL20,RNF144B,GAN,WWP1,TRIM41,ASB9 |
| Antigen processing: Ubiquitination & | TRIM69,UBR2,FBXO3,RNF123,RNF34,RNF4,TRAF7,ASB11,TPP2,TRIM11 |
Protein Function
RNF111 has several biochemical functions, for example, SMAD binding,SUMO polymer binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF111 itself. We selected most functions RNF111 had, and list some proteins which have the same functions with RNF111. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | KDM5B,MT1B,PHF15,TNKS,ZDHHC6,CRIP2,NR1I2,SP140L,NR2F1,TRIM43 |
| SUMO polymer binding | RNF222,SIMC1,SOBP,RNF4 |
| ligase activity | KCMF1,SHPRH,ATG10,TRIM11,BIRC7,UBE2D1B,KCNG4,TRAF3,UBE2IA,PCXA |
| SMAD binding | SKOR1,EP300,PRDM16,PURA,TGFBRAP1,SKOR1A,MEF2A,TCF12,PURB,COL3A1 |
| ubiquitin protein ligase activity | PDZD4,UBE2V2,RNF152,STUB1,RNF115,ITCH,MED23,MED21,FBXL22,UBE2T |
| protein binding | NPHS1,SCNM1,DTX2,SHE,MPPE1,NKX2-5,NUDT14,CALCOCO1,PIK3CA,NPDC1 |
Interacting Protein
RNF111 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF111 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF111.
UBE2D1;UBE2D3;UBE2I;KRTAP5-9;CSNK2A1
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References
- Jimeno, S; Fernandez-Avila, MJ; et al. Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. NUCLEIC ACIDS RESEARCH 43:987-999(2015).
- Sun, HY; Liu, YJ; et al. Multiple Arkadia/RNF111 Structures Coordinate Its Polycomb Body Association and Transcriptional Control. MOLECULAR AND CELLULAR BIOLOGY 34:2981-2995(2014).
