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Official Full Name ring finger protein 146
Background RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene.
Synonyms RNF146; ring finger protein 146; E3 ubiquitin-protein ligase RNF146; dactylidin; dJ351K20.1; DKFZp434O1427; RP3 351K20.1; RN146_HUMAN; RNF 146; 2610509H23Rik; RP3-351K20.1
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF146-2292HCL Recombinant Human RNF146 293 Cell Lysate HEK293 N/A
    Human RNF146-434H Recombinant Human RNF146 Protein, His-tagged E.coli His
    Cynomolgus Monkey RNF146-860C Recombinant Cynomolgus RNF146 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque RNF146-3933R Recombinant Rhesus monkey RNF146 Protein, His-tagged Mammalian Cell His
    Zebrafish RNF146-10227Z Recombinant Zebrafish RNF146 Mammalian Cell His

    RNF146 involved in several pathways and played different roles in them. We selected most pathways RNF146 participated on our site, such as Degradation of AXIN, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF146 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of AXIN TNKS; RNF146; TNKS2
    Signal Transduction SKI; HEYL; IFT172; PMCH; SOX4B; OXGR1A.3; OPN5; GPR31; RDH14A; MDK
    Signaling by Wnt LEO1; FMNL3; RSPO1; SOX4B; LGR5; RNF43; SOX13; HECW1; C; RSPO3
    TCF dependent signaling in response to WNT SOX9A; RBBP5; SOX32; BCL9; RSPO2; SOX9B; HECW1B; LGR6; USP34; SOX7

    RNF146 has several biochemical functions, for example, ligase activity, poly-ADP-D-ribose binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF146 itself. We selected most functions RNF146 had, and list some proteins which have the same functions with RNF146. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity TTLL5; RNF125; PIAS1; TRAIP; GLULC; TTLL11; TRIM32; UBE2IB; RNF123; TRAF2
    poly-ADP-D-ribose binding RNF146
    protein binding NPLOC4; EIF4G1; PGAP2; RAD23B; DYNLRB1; KDM5B; KAL1; SOX2; PEX26; FBXL8
    ubiquitin protein ligase activity UBE2NB; STUB1; UHRF2; FBXW11; HERC5; RNF34; WWP1; UBE2B; RAD18; HUWE1
    ubiquitin-protein transferase activity UBE2S; BARD1; MIB2; FBXO7; UBE3C; MARCH5L; TRAF4B; PJA2; BTR22; LRSAM1
    zinc ion binding NR4A1; USP51; HE1B; ADAMTS12; GATA3; RPH3A; PDLIM3B; ZNF212; RNF126; TRIM35-24

    RNF146 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF146 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF146.

    TRAF2; CCDC155; TUBGCP4; Sh3bp2; PFN2; UBE2G2; UBE2H

    Gero, D; Szoleczky, P; et al. Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes. MOLECULAR MEDICINE 20:313-328(2014).
    Gao, Y; Song, CY; et al. Overexpression of RNF146 in Non-Small Cell Lung Cancer Enhances Proliferation and Invasion of Tumors through the Wnt/beta-catenin Signaling Pathway. PLOS ONE 9:-(2014).

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