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Official Full Name ring finger protein (C3H2C3 type) 6
Background The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
Synonyms RNF6; ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase RNF6; DKFZp686P0776; RING H2 protein RNF 6; Ring finger protein 6; RING H2 protein; RING H2 protein RNF6; RNF 6; OTTHUMP00000018154; OTTHUMP00000018155; OTTHUMP00000018156; RING-H2 protein RNF-6
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF6-1529HCL Recombinant Human RNF6 cell lysate N/A
    Human RNF6-2348H Recombinant Human RNF6, His-tagged E.coli His
    Mouse RNF6-14353M Recombinant Mouse RNF6 Protein Mammalian Cell His

    rnf6 involved in several pathways and played different roles in them. We selected most pathways rnf6 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with rnf6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System KIF3C; AP1G1; MGC174155; ASB4; CSK; CD300A; OSBPL1A; KIF18A; UBE2U; CTSC
    Androgen receptor signaling pathway CREBBP; CCDC102A; RNF4; CMTM2A; JUN; ZMIZ1; AES; RAD54L2; PSMC3IP; HTATIP
    Antigen processing: Ubiquitination &amp UBA5; UBE2J2; STUB1; SPSB1; RNF220; LRRC41; ASB9; SPSB4; LRSAM1; BLMH
    Proteasome degradation RNF123; TRIM11; RNF144B; TRIM63; ARIH2; UBE2V2; UFL1; WWP1; ASB13; TRAF7
    Class I MHC mediated antigen processing &amp UBE2V2; RNF34; LRSAM1; SH3RF1; UBR1; SEC24A; TRAF7; TRIM39; ASB7; UBE2F
    presentation ARIH2; TRIM9; ASB7; UFL1; UBR1; FCGR1B; FBXO3; UBE2U; LTN1; RNF4
    Immune System EIF4G2A; CD300LG; IRF9; POLR3G; TRIM56; TRIM3; BTR16; AP1B1; LILRB2; KLC3

    rnf6 has several biochemical functions, for example, DNA binding, androgen receptor binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rnf6 itself. We selected most functions rnf6 had, and list some proteins which have the same functions with rnf6. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding GTF2A1; ZFP580; MECOM; ZNF559-ZNF177; ELF2A; SP140; NR4A2A; TRIM21; TLX3B; HIST1H110
    androgen receptor binding CCNE1; PIAS2; NCOA4; KDM3A; FOXP1; TRIM68; PRKCB; FOXH1; PKN1; KAT5
    ligase activity RAG1; MUL1A; ADSSL; RING1; RNF25; TRIM32; TOPORS; HERC5; SYVN1; G2E3
    protein binding SHC3; OGN; IPO5; ZNF41; SPRY4; KITLG; ACP1; RUSC1-AS1; OLR1; IL17RE
    ubiquitin protein ligase activity MYLIP; PDZRN3B; TRIM2; SIAH2; TRIM59; MED23; RNF19A; RNF175; SMURF1; TRIM6
    ubiquitin-protein transferase activity UHRF1; TTC3; UBR4; MARCH2; BRAP; LMO7; MYLIP; TRIM28; FLJ11011L; DZIP3
    zinc ion binding ASH1L; PDZRN3B; TRIM35-7; LIMK1A; UQCRC2B; LHX2A; DPP3; RARAA; MEP1A.1; TRIM45

    rnf6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rnf6 here. Most of them are supplied by our site. Hope this information will be useful for your research of rnf6.

    AR; UBE2H; bmf_human_gene; rel1_human_gene; klk3_human_gene; RNF14

    Stoll, H; et al. Filling the Gap between Pseudopotential and All-Electron Schemes: Frozen-Core Calculations with Efficient Use of Density-Fitting. JOURNAL OF CHEMICAL THEORY AND COMPUTATION 10:3857-3862(2014).
    Linn, DE; Yang, X; et al. Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-dependent Recruitment of Distinct Ubiquitin E3 Ligases. JOURNAL OF BIOLOGICAL CHEMISTRY 287:22959-22968(2012).

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