RPS6KA5 involved in several pathways and played different roles in them. We selected most pathways RPS6KA5 participated on our site, such as MAPK signaling pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
RPS6KA3A; ECSIT; PPM1NA; TAOK1; PPM1AA; RPS6KAL; CACNA1SB; GADD45AA; CACNB3A; MAP2K2 |
| Adrenergic signaling in cardiomyocytes |
GNAI2B; TNNT2A; MAPK12; CACNG7A; ADRB2B; CALM1; PPP2R3A; ATP1A2A; CAMK2B1; PLCB2 |
| TNF signaling pathway |
MAPK10; TRAF2; TRAF5; CCL20; SOCS3; IL1B; CASP7; CCL5; MAPK9; FOS |
| Circadian entrainment |
PRKCA; CALML3; CALM1; GRIA1; GNGT1; PLCB4; GNG3; GNB3; GNAO1; GRIA3 |
| Neurotrophin signaling pathway |
AKT2; RHOA; GRB2; MAP3K3; MATK; SHC3; GAB1; MAP2K7; YWHAE; ZNF274 |
| MicroRNAs in cancer |
TPM1; PRKCA; CDC25C; BAK1; PTGS2; DNMT1; PRKCE; SLC7A1; CCNE1; GLS2 |
| Bladder cancer |
RASSF1; MYC; E2F1; UPK3A; SRC; MMP9; MDM2; E2F2; ARAF; RAF1 |
RPS6KA5 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-S10 specific), magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA5 itself. We selected most functions RPS6KA5 had, and list some proteins which have the same functions with RPS6KA5. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
MAP3K10; FYN; ADCY1; NEK1; CHTF18; TTLL3; CHD4A; LANCL2; MYO1F; CDC34 |
| histone kinase activity (H3-S10 specific) |
VRK1; RPS6KA5; RPS6KA4 |
| magnesium ion binding |
IRAK4; PPM1BA; TESC; GSS; MTPAP; IMPA1; ATP9A; ERN1; IDH3B; HMGCL |
| protein binding |
L3MBTL1; INCENP; PIM3; DPYSL4; LSM11; CASC3; NSG1; TRIM74; PDGFRA; COMMD3 |
| protein kinase activity |
MAPK12B; ARAF; CDK1; RASSF2; PRKAA1; MKNK2A; DCLK1; PRKCG; SRC; PRKCHB |
| protein serine/threonine kinase activity |
RPS6KB1B; TAOK1; PRKDC; SNRKB; MYLK4; MLKL; RPS6KA5; MKNK2; ADCK4; SMOK3B |
RPS6KA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA5.
ZAK; RELA; saicar; MAPT; PKM; EGF; NR3C1; HSP90AB1; ATF2; NR4A1; PDLIM1; SMAD6; DDAH2; FN1; RPA1; ACTG1
Lemeer, S; Gholami, AM; et al. Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. PROTEOMICS 15:356-364(2015).
Aliabadi, HM; Maranchuk, R; et al. Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy. JOURNAL OF CONTROLLED RELEASE 172:219-228(2013).
