RPS6KA5
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Official Full Name
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -
Synonyms
RPS6KA5;ribosomal protein S6 kinase, 90kDa, polypeptide 5;ribosomal protein S6 kinase, 90kD, polypeptide 5;ribosomal protein S6 kinase alpha-5;MSK1;RLPK;RSKL;S6K-alpha-5;RSK-like protein kinase;90 kDa ribosomal protein S6 kinase 5;nuclear mitogen- and stress-activated protein kinase 1;MSPK1;MGC1911
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Insect Cells
- Sf21 Cells
- His
- Non
- GST
- DDK
- Myc
- Avi
- Fc
Involved Pathway
RPS6KA5 involved in several pathways and played different roles in them. We selected most pathways RPS6KA5 participated on our site, such as MAPK signaling pathway,Adrenergic signaling in cardiomyocytes,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF6,MAP2K6,MAPKAPK3,FGFR4,ARR3A,RELA,CACNG1A,RAC1A,NTRK1,PRKACBB |
| Adrenergic signaling in cardiomyocytes | ADRA1D,ADRB3B,AKT2,PRKACG,RYR2,PPP1CBL,MYL3,PPP1CA,CREB3L1,CACNA2D2 |
| MicroRNAs in cancer | Abcb1b,FGFR3,TNR,IRS1,SOS1,PDGFB,Pdgfa&Pdgfb,CDC25C,TGFB2,MAPK7 |
| TNF signaling pathway | TRAF3,DNM1L,MAP2K3,CCL2,BAG4,CASP8,IKBKB,PGAM5,PIK3R2,CREB5 |
| Neurotrophin signaling pathway | PDPK1,ATF4,NFKBIA,MAP3K5,MATK,MAP2K5,RAPGEF1,MAPKAPK2,ZFP110,BRAF |
| Bladder cancer | KRAS,TP53,EGF,THBS1,RB1,MAP2K2,MMP1,MAPK3,HRAS,VEGFA |
| Circadian entrainment | GRIN2C,CACNA1H,GRIN2B,GNAS,CALM4,GUCY1A3,KCNJ9,CAMK2G,GNAI3,PRKG2 |
Protein Function
RPS6KA5 has several biochemical functions, for example, ATP binding,histone kinase activity (H3-S10 specific),magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA5 itself. We selected most functions RPS6KA5 had, and list some proteins which have the same functions with RPS6KA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | EEF2K,RPS6KA3A,DYRK1B,MAP2K4,ACVR1BA,NIM1,TLK1B,DCLK1,AKT1,RAF1B |
| protein serine/threonine kinase activity | TGFBR1B,TAOK1,STK31,NLK2,VRK3,ULK4,MAP3K11,IRAK1,STK17B,PAK2B |
| ATP binding | MCM3L,CDC6,NME7,TTLL10,SNRKA,EHD2,IP6K2,UBE2Z,MAST2,BAZ1B |
| magnesium ion binding | RRAGC,NEK6,CIB4,MAST4,PKMB,NT5C3A,TSSK4,THTPA,RPS6KAL,TESC |
| histone kinase activity (H3-S10 specific) | VRK1,RPS6KA4 |
| protein binding | BRPF1,ACVR1B,NR1H3,CLU,ATL1,YIPF3,FANCA,ZAK,INTS7,VLDLR |
Interacting Protein
RPS6KA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA5.
ZAK;RELA;saicar;MAPT;PKM;EGF;NR3C1;HSP90AB1;ATF2;NR4A1;PDLIM1;SMAD6;DDAH2;FN1;RPA1;ACTG1
RPS6KA5 Related Signal Pathway
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References
- Lemeer, S; Gholami, AM; et al. Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. PROTEOMICS 15:356-364(2015).
- Aliabadi, HM; Maranchuk, R; et al. Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy. JOURNAL OF CONTROLLED RELEASE 172:219-228(2013).
