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RRP8

  • Official Full Name

    ribosomal RNA processing 8, methyltransferase, homolog (yeast)

  • Overview

    Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene.
  • Synonyms

    RRP8; ribosomal RNA processing 8, methyltransferase, homolog (yeast); KIAA0409; ribosomal RNA-processing protein 8; RRP8 methyltransferase homolog (S. cerevisiae); Cerebral protein 1; hypothetical protein LOC23378; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing protein 8; RRP 8; RRP8 methyltransferase homolog;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RRP8-2140HCL Recombinant Human RRP8 293 Cell Lysate HEK293 N/A
Human RRP8-2469H Recombinant Human RRP8 protein(81-270 aa), C-His-tagged E. coli C-His 81-270 aa
Mouse RRP8-14534M Recombinant Mouse RRP8 Protein Mammalian Cell His
Mouse RRP8-7821M Recombinant Mouse RRP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RRP8-7821M-B Recombinant Mouse RRP8 Protein Pre-coupled Magnetic Beads HEK293
Rat RRP8-5184R Recombinant Rat RRP8 Protein Mammalian Cell His
Rat RRP8-4843R Recombinant Rat RRP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RRP8-4843R-B Recombinant Rat RRP8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RRP8 Related Articles

RRP8 involved in several pathways and played different roles in them. We selected most pathways RRP8 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, Negative epigenetic regulation of rRNA expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Epigenetic regulation of gene expressionTET1;SAP30;RBB4L;TET2;CD3EAP;SAP18;TAF1D;SUDS3;SUZ12
Gene ExpressionZNF331;METTL14;SNAPC4;MED31;NR2F1B;THG1L;SAP30;ZNF257;ZFP1
Negative epigenetic regulation of rRNA expressionSAP130;TAF1A;SIN3B;DNMT3B;SUDS3;SAP30BP;EFCAB11;TAF1B;CD3EAP
SIRT1 negatively regulates rRNA Expression

RRP8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, methylated histone binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRP8 itself. We selected most functions RRP8 had, and list some proteins which have the same functions with RRP8. You can find most of the proteins on our site.

Function Related Protein
S-adenosylmethionine-dependent methyltransferase activityMETTL7A;LCMT1;RRP8;ASMT2;WBSCR27;C6orf211;SUV39H1;COQ5;PRMT8B
methylated histone bindingING4;KAT8;RBBP5;WDR92;CBX5;CCDC101;KDM4A;L3MBTL1;ING3
poly(A) RNA bindingHIST1H4E;DIEXF;EIF2S1A;TRMT6;RBM4;RPL36;PCBP1;DDX10;MRPL10
protein bindingMAGEA3;FLII;HERPUD1;TXNDC9;NRBF2;WDFY2;CCNB1;MED18;CDH5

RRP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRP8.

SUV39H1; SIRT1; h3_peptide-2-21; s-adenosyl-l-methionine-1; USP39; BALF3 (provisional); MNDA; ILK

Sharma, S; Watzinger, P; et al. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. NUCLEIC ACIDS RESEARCH 41:5428-5443(2013).
Peifer, C; Sharma, S; et al. Yeast Rrp8p, a novel methyltransferase responsible for m(1)A 645 base modification of 25S rRNA. NUCLEIC ACIDS RESEARCH 41:1151-1163(2013).
Schilling, V; Peifer, C; et al. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. YEAST 29:167-183(2012).
Bousquet-Antonelli, C; Vanrobays, E; et al. Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2. RNA-A PUBLICATION OF THE RNA SOCIETY 6:826-843(2000).
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