Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

RTEL1

  • Official Full Name

    regulator of telomere elongation helicase 1

  • Overview

    In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene.
  • Synonyms

    RTEL1; regulator of telomere elongation helicase 1; C20orf41, chromosome 20 open reading frame 41; bK3184A7.3; DKFZP434C013; KIAA1088; NHL; RTEL; C20orf41; Chromosome 20 open reading frame 41; Novel helicase like; Regulator of telomere length; RP4-583P15.2; OTTHUMP00000031577; OTTHUMP00000184892; OTTHUMP00000221856;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RTEL1-15HCL Recombinant Human RTEL1 Over-expression Lysate, C-Myc/DDK tagged HEK293T C-Myc/DDK
Mouse RTEL1-14562M Recombinant Mouse RTEL1 Protein Mammalian Cell His
Mouse RTEL1-7837M Recombinant Mouse RTEL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RTEL1-7837M-B Recombinant Mouse RTEL1 Protein Pre-coupled Magnetic Beads HEK293
Rat RTEL1-5191R Recombinant Rat RTEL1 Protein Mammalian Cell His
Rat RTEL1-4850R Recombinant Rat RTEL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RTEL1-4850R-B Recombinant Rat RTEL1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RTEL1-2106Z Recombinant Zebrafish RTEL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RTEL1 Related Articles

RTEL1 involved in several pathways and played different roles in them. We selected most pathways RTEL1 participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), which may be useful for your reference. Also, other proteins which involved in the same pathway with RTEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Double-Strand Break RepairPPP4CB;RAD50;HTATIP;TOPBP1;WRN;TP53BP1;RAD9A;PAXIP1;BAZ1B
DNA RepairPPIE;PARP1;ACTR5;PIAS3;PPP4CA;TDP2;TIPIN;BRE;EME1
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)EME1;HUS1;RHNO1;PPP4CA;BABAM1;RAD9;PPP4R2;EME2;PPP4R2B
HDR through Homologous Recombination (HRR)EME2;KIAA0146;RBBP8;TOPBP1;EME1;RHNO1;RAD9;RAD51AP1;GEN1
Homology Directed RepairRNF4;PPP4R2B;PPP4CB;PPP4R2A;WRN;RTEL1;GEN1;KIAA0146;RAD51AP1
Resolution of D-Loop StructuresRAD51AP1;GEN1;RTEL1;EME2;KIAA0146
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

RTEL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RTEL1 itself. We selected most functions RTEL1 had, and list some proteins which have the same functions with RTEL1. You can find most of the proteins on our site.

Function Related Protein
4 iron, 4 sulfur cluster bindingNUBP1;ACO2;MUTYH;ERCC2;BRIP1;ISCUB;TYW1;TYW1B;DEM1
ATP bindingTRAP1;TLK1A;RPS6KA3;TP53RK;BBS12;CHD1;RPS6KA3B;MAGI3;DDX56
ATP-dependent DNA helicase activityXRCC5;DDX3X;CHST13;CHD1;FBXO18;GTF2H4;DHX9;BLM;CHD4
ATP-dependent helicase activityDHX37;DHX36;RTEL1;BLM;SNRNP200;CHD6;TTF2;RECQL5;ERCC6L2
DNA bindingPOU3F1;CREM;MYCL1;CEBPG;EBF2;EN1;SPHK1;ZNF599;RORC
helicase activityCHD7;MCM3L;CHD8;SMARCA5;MOV10;HELLS;EIF4A1A;DDX19;DQX1
hydrolase activityPIF1;ABHD6B;PSMB8F;GNPDA1;PPAP2C;SNRNP200;REXO1;MCM6L;MEIOB
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesCHD4A;BLM;RTEL1
iron-sulfur cluster bindingNDUFS1;AIFM4;CISD3;RTEL1;CMAH;PROZA;AOX3L1;AOX3;AOX4
metal ion bindingZNF187;METAP2A;NGLY1;SAP30;GLRX5;ZSCAN12;REST;USP4;CACNA1D
nucleic acid bindingRNASE4;YY1A;PL10;SRSF6A;BHLHE22;ZIC5;PRDM13;EWSR1B;KLF12B
nucleotide bindingSMC5;TUBA1L;MAPKAPK2A;OASL2;ACTB2;PUF60A;CELF2;RBMS3;ACSL1

RTEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RTEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RTEL1.

Pei, SJ; Zhao, F; et al. Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:690-697(2015).
Recker, J; Knoll, A; et al. The Arabidopsis thaliana Homolog of the Helicase RTEL1 Plays Multiple Roles in Preserving Genome Stability. PLANT CELL 26:4889-4902(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All RTEL1 Products

Required fields are marked with *

My Review for All RTEL1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends