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SCYL1

Official Full Name

SCY1-like 1 (S. cerevisiae)
Overview

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SCYL1; SCY1-like 1 (S. cerevisiae); N terminal kinase like , NTKL; N-terminal kinase-like protein; GKLP; HT019; MGC78454; NKTL; P105; TAPK; TEIF; telomerase regulation associated protein; telomerase transcriptional elements interacting factor; teratoma associated tyrosine kinase; TRAP; Coated vesicle associated kinase of 90 kDa; CVAK90; Likely ortholog of mouse N terminal kinase like protein; N terminal kinase like; N terminal kinase like protein; NTKL; NTKLBP1; SCY L1; SCY1 like 1; SCY1 like 1 protein 1; SCYL 1; SCYL1BP1; Telomerase transcriptional element interacting factor; SCY1-like protein 1; teratoma-associated tyrosine kinase; telomerase regulation-associated protein; coated vesicle-associated kinase of 90 kDa; telomerase transcriptional element-interacting factor; telomerase transcriptional ele;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SCYL1-536H	Recombinant Human SCYL1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	SCYL1-5555H	Recombinant Human SCYL1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	SCYL1-14785M	Recombinant Mouse SCYL1 Protein	Mammalian Cell	His	Inquiry
Mouse	SCYL1-7954M	Recombinant Mouse SCYL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	Scyl1-5726M	Recombinant Mouse Scyl1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	SCYL1-7954M-B	Recombinant Mouse SCYL1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	SCYL1-5282R	Recombinant Rat SCYL1 Protein	Mammalian Cell	His	Inquiry
Rat	SCYL1-4941R	Recombinant Rat SCYL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	SCYL1-4941R-B	Recombinant Rat SCYL1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SCYL1 Related Articles

SCYL1 involved in several pathways and played different roles in them. We selected most pathways SCYL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SCYL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SCYL1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCYL1 itself. We selected most functions SCYL1 had, and list some proteins which have the same functions with SCYL1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	GUCY2E;GNE;SRX1;UBA7;LIG1;UBE2A;PNCK;MCM6L;ATAD5
protein binding	CNPY2;RPAP3;GRB10;FBXL19;E2F4;THOP1;DENND2D;CRTAC1;MXD3
protein kinase activity	PHKG1B;PRKCBB;ABL2;HIPK3B;CDK5R1;RPS6KA3;Fert2;CDK11A;MKNK2B

SCYL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCYL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCYL1.

Schmidt, WM; Kraus, C; et al. Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration. EMBO REPORTS 8:691-697(2007).