SEC23IP
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Official Full Name
SEC23 interacting protein -
Overview
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
SEC23IP;SEC23 interacting protein;SEC23-interacting protein;P125;MSTP053;Phospholipase;Sec23 interacting protein p125;OTTHUMP00000020613;P125A
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SEC23IP-2564H | Recombinant Human SEC23IP, GST-tagged | E.coli | Human | GST | C-350aa | |
| SEC23IP-4711Z | Recombinant Zebrafish SEC23IP | Mammalian Cells | Zebrafish | His |
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| SEC23IP-1992HCL | Recombinant Human SEC23IP 293 Cell Lysate | HEK293 | Human | Non |
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| Sec23ip-5746M | Recombinant Mouse Sec23ip Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
SEC23IP involved in several pathways and played different roles in them. We selected most pathways SEC23IP participated on our site, such as Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport,ER to Golgi Anterograde Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC23IP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| COPII (Coat Protein 2) Mediated Vesicle Transport | PPP6R3,GOLGA2,TFG,MCFD2,CSNK1D,NAPAB,TRAPPC5,TRAPPC2,TRAPPC6BL,PREB |
| Transport to the Golgi and subsequent modification | PPP6R1,SEC22A,MGAT4B,TRAPPC6BL,TRAPPC10,CNIH3,CNIH,CNIH2,LMAN2L,TRAPPC2 |
| Membrane Trafficking | TCEAL4,DAB2,BLOC1S4,STAM2,NECAP1,TRAPPC4,TFG,SCFD1,GJB7,GJA5 |
| Vesicle-mediated transport | TBC1D8B,MYO6A,PICALMB,HPX,SEC22A,HSPH1,AP3S1,DTNBP1B,TERFA,PUM1 |
| Asparagine N-linked glycosylation | MAGT1,TRAPPC6BL,OS9,TRAPPC3,SERPINA1L,TRAPPC6A,NSFA,MAN1B1,GNE,PPP6R3 |
| Metabolism of proteins | KLHDC3,LTF,ACE,CPN1,SENP5,A4GNT,FBXW2,NSMCE4A,ADAMTSL1,CTDSP2 |
| ER to Golgi Anterograde Transport | GORASP1,TRAPPC10,ANKRD28,BET1,TMED2,SEC22A,NSFA,TRAPPC2L,PPP6R3,MIA3 |
| Post-translational protein modification | NSMCE4A,SCMH1,UBA2,ADAMTS18,MLEC,MUCL1,WDR85,GCNT3,PPP6R3,SEC22C |
Protein Function
SEC23IP has several biochemical functions, for example, metal ion binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC23IP itself. We selected most functions SEC23IP had, and list some proteins which have the same functions with SEC23IP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | G3BP2,RSL1D1,SERBP1,ZFML,HIST4H4,THUMPD1,OASL,RPL19,RIMS1,SAFB |
| metal ion binding | ZKSCAN1,HPDL,MYOC,PVALB1,ZNF664,EGR3,RORAA,ADAM25,CYP2D10,ZBTB12.2 |
| protein binding | KIF7,DDX55,DGCR6L,XRCC5,SIRT2,ETV5,E2F3,MOAP1,ZNF473,GFI1B |
Interacting Protein
SEC23IP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC23IP here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC23IP.
SSC5D;HSPB11;PDCD6;Sec24c;Kif4;PRKD2;Vps28;TIMM13
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References
- de Barsy, M; Mirabella, A; et al. A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells. MICROBIOLOGY-SGM 158:2610-2618(2012).
