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Official Full Name SUMO1/sentrin/SMT3 specific peptidase 3
Background The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are;responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the;conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO;conjugates (Di Bacco et al., 2006 (PubMed 16738315)).
Synonyms SENP3; SUMO1/sentrin/SMT3 specific peptidase 3; SUMO1/sentrin/SMT3 specific protease 3; sentrin-specific protease 3; DKFZP586K0919; DKFZp762A152; SMT3IP1; SSP3; Ulp1; SUMO-1-specific protease 3; sentrin/SUMO-specific protease 3
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SENP3-1974HCL Recombinant Human SENP3 293 Cell Lysate HEK293 N/A
    Human SENP3-2577H Recombinant Human SENP3, His-tagged E.coli His
    Mouse SENP3-14880M Recombinant Mouse SENP3 Protein Mammalian Cell His

    SENP3 involved in several pathways and played different roles in them. We selected most pathways SENP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    SENP3 has several biochemical functions, for example, SUMO-specific protease activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP3 itself. We selected most functions SENP3 had, and list some proteins which have the same functions with SENP3. You can find most of the proteins on our site.

    Function Related Protein
    SUMO-specific protease activity SENP5; SENP3B; SENP6; SENP1; SENP3A; SENP3
    endopeptidase activity KLK1B1; MMP3; ACE; TPP1; NAPSA; HTRA4; PSMA6; SENP1; PCSK6; CTSH
    protein binding AP3S1; SMURF1; ING4; TLX1; SERP2; ROPN1L; IFNA4; CADM1; NEUROG3; AURKA

    SENP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP3.

    NPM1; PELP1; UBC; WDR18; TEX10; CDK4; CDK6

    Yang, YQ; Li, H; et al. Expression and Cell Distribution of SENP3 in the Cerebral Cortex After Experimental Subarachnoid Hemorrhage in Rats: A Pilot Study. CELLULAR AND MOLECULAR NEUROBIOLOGY 35:407-416(2015).
    Raman, N; Nayak, A; et al. mTOR Signaling Regulates Nucleolar Targeting of the SUMO-Specific Isopeptidase SENP3. MOLECULAR AND CELLULAR BIOLOGY 34:4474-4484(2014).

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