SEPT4

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SEPT4

Official Full Name septin 4
Background This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
Synonyms SEPT4; septin 4; H5; ARTS; MART; SEP4; CE5B3; PNUTL2; hucep-7; BRADEION; hCDCREL-2; septin-4; septin-M; CE5B3 beta; bradeion beta; brain protein H5; cerebral protein 7; peanut-like protein 2; cell division control-related protein 2; apoptosis-related protein in the TGF-beta signaling pathway;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEPT4-1958HCL Recombinant Human SEPT4 293 Cell Lysate HEK293 N/A
    Human SEPT4-1959HCL Recombinant Human SEPT4 293 Cell Lysate HEK293 N/A
    Human SEPT4-1960HCL Recombinant Human SEPT4 293 Cell Lysate HEK293 N/A
    Mouse SEPT4-14894M Recombinant Mouse SEPT4 Protein Mammalian Cell His
    Cynomolgus Monkey SEPT4-910C Recombinant Cynomolgus SEPT4 Protein, His-tagged Mammalian Cell His

    SEPT4 involved in several pathways and played different roles in them. We selected most pathways SEPT4 participated on our site, such as Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis Modulation and Signaling DIABLO; SEPT4; PTPN13; HRK; CDKN2A; BIK; DFFA; BLK; CASP2; CRADD

    SEPT4 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT4 itself. We selected most functions SEPT4 had, and list some proteins which have the same functions with SEPT4. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding GNAQ; RASD2; IFT22; NKIRAS1; DNM2A; ARL4CA; ACSM1; MFHAS1; ATL2; ACSM5
    GTPase activity EEFSEC; ARL4C; GFM2; EIF5B; RRAGC; RAB15; IIGP1; GTPBP10; GBP5; RAB40AL
    protein binding MCCC1; SMAGP; CRY1A; RASSF2; FBN1; DDA1; CTCFL; OSTB; FGF21; CHEK2
    structural molecule activity KRT9; PGM5; CLDNH; PNN; KRT95; KRT4; CLDND; MATR3; SPRR4; INAA

    SEPT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT4.

    RB1; NR4A1; SIAH1; TNIK; SEPT14; SEPT12; Caskin1

    Hosseinifar, H; Shafipour, M; et al. Relationship between absence of annulus and asthenozoospermia in Iranian men. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 31:1681-1685(2014).
    Guan, JK; Kinoshita, M; et al. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. BMC DEVELOPMENTAL BIOLOGY 9:-(2009).

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