sf3a2 Protein, splicing factor 3a, subunit 2, 66kDa


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Official Full Name splicing factor 3a, subunit 2, 66kDa
Background This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.
Synonyms SF3A2; splicing factor 3a, subunit 2, 66kDa; splicing factor 3a, subunit 2, 66kD; splicing factor 3A subunit 2; Prp11; PRPF11; SAP62; SF3a66; Spliceosome-associated protein 62; SAP 62; spliceosome associated protein 62; pre-mRNA splicing factor SF3A, subunit 2
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SF3A2-2611H Recombinant Human SF3A2, His-tagged E.coli His
    Rat SF3A2-5351R Recombinant Rat SF3A2 Protein Mammalian Cell His
    Chicken SF3A2-1215C Recombinant Chicken SF3A2 Mammalian Cell His
    Zebrafish SF3A2-11273Z Recombinant Zebrafish SF3A2 Mammalian Cell His

    sf3a2 involved in several pathways and played different roles in them. We selected most pathways sf3a2 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with sf3a2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome TTC6; FAM120B; AQR; THOC2; DHX15; MAGOH2; DDX39B; TRA2A; CCDC12; SRSF6B

    sf3a2 has several biochemical functions, for example, poly(A) RNA binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sf3a2 itself. We selected most functions sf3a2 had, and list some proteins which have the same functions with sf3a2. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding PRAC; IFIT5; LARP4B; ZFP768; SEC23IP; SAMSN1; EIF3A; RPS4Y1; NOP56; THOC4
    protein binding NR4A3; EVI5; ALDOC; CAV1; FAF1; NRXN1; DCTPP1; RPS6KA5; RGS3; ATP1B2
    zinc ion binding PYGO1; RNF31; NR4A2B; PRKCBP1L; ZFAND1; ADAT3; NR1D2; PTPN1; BRF1B; PHF14

    sf3a2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sf3a2 here. Most of them are supplied by our site. Hope this information will be useful for your research of sf3a2.

    SF3A1; DHX15; SF1; CDC5L; nm_004500.2; nm_006387.4; nm_014281.3; nm_016403.2; nm_018011.2; nm_033537.1; nm_144604.2; TCERG1; SART1; HNRNPR; PRPF3

    Hirokawa, M; Morita, H; et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. EUROPEAN JOURNAL OF HUMAN GENETICS 23:374-380(2015).
    Maitra, R; Sadofsky, MJ; et al. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified proteinprotein interactions. NUCLEIC ACIDS RESEARCH 37:3301-3309(2009).

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