SH2B1

Official Full Name

SH2B adaptor protein 1
Overview

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
Synonyms

SH2B1; SH2B adaptor protein 1; SH2B adapter protein 1; FLJ30542; SH2 B homolog; SH2B; DKFZp547G1110; KIAA1299; Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 B; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; SH2-B signaling protein; SH2B1 protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SH2B1-1596HCL	Recombinant Human SH2B1 cell lysate		Non	Inquiry
Human	SH2B1-1340H	Recombinant Human SH2B1 Protein, MYC/DDK-tagged	HEK293	Myc&DDK	Inquiry
Mouse	SH2B1-15051M	Recombinant Mouse SH2B1 Protein	Mammalian Cell	His	Inquiry
Mouse	SH2B1-8113M-B	Recombinant Mouse SH2B1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	SH2B1-8113M	Recombinant Mouse SH2B1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Mouse	Sh2b1-5832M	Recombinant Mouse Sh2b1 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK	Inquiry
Rat	SH2B1-5371R	Recombinant Rat SH2B1 Protein	Mammalian Cell	His	Inquiry
Rat	SH2B1-5030R	Recombinant Rat SH2B1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rat	SH2B1-5030R-B	Recombinant Rat SH2B1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SH2B1-6176Z	Recombinant Zebrafish SH2B1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SH2B1 involved in several pathways and played different roles in them. We selected most pathways SH2B1 participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neurotrophin signaling pathway	CALML5;RIPK2;MAP3K1;CAMK2A;ABL1;RPS6KA6;MAPK3;MAPK11;NGF

SH2B1 has several biochemical functions, for example, protein binding, signal transducer activity, signaling adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B1 itself. We selected most functions SH2B1 had, and list some proteins which have the same functions with SH2B1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	IFT43;CSE1L;ING2;AKAP5;SOX4;ALOX12B;FOXO4;BPIFA2;MCC
signal transducer activity	GNA13B;GNG13A;GPR113;TAS2R106;GNA11B;OLFR478;ASZ1;VMN1R40;TACR1A
signaling adaptor activity	LDLRAP1;MPP7;SH2B3;AFAP1L2;HOMER1;GNB2L1;SH2B2;SH2B1

SH2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B1.

EGFR; JAK2; Stat3; INSR; MET; STAT3; Stat3; KIAA0319