SH2B1
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Official Full Name
SH2B adaptor protein 1
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Overview
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. -
Synonyms
SH2B1; SH2B adaptor protein 1; SH2B adapter protein 1; FLJ30542; SH2 B homolog; SH2B; DKFZp547G1110; KIAA1299; Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 B; SH2 domain-containing protein 1B; SH2 domain-containing putative adapter SH2-B; SH2-B signaling protein; SH2B1 protein;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SH2B1-1596HCL | Recombinant Human SH2B1 cell lysate | N/A |
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| Human | SH2B1-1340H | Recombinant Human SH2B1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Mouse | SH2B1-15051M | Recombinant Mouse SH2B1 Protein | Mammalian Cell | His |
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| Mouse | SH2B1-8113M-B | Recombinant Mouse SH2B1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | SH2B1-8113M | Recombinant Mouse SH2B1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Sh2b1-5832M | Recombinant Mouse Sh2b1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | SH2B1-5371R | Recombinant Rat SH2B1 Protein | Mammalian Cell | His |
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| Rat | SH2B1-5030R | Recombinant Rat SH2B1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | SH2B1-5030R-B | Recombinant Rat SH2B1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | SH2B1-6176Z | Recombinant Zebrafish SH2B1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- SH2B1 Related Research Area
SH2B1 involved in several pathways and played different roles in them. We selected most pathways SH2B1 participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | PSEN2;MAP2K7;CAMK2D;IRS1;MAPK8;IKBKB;IRAK4;RPS6KA3;HRAS |
SH2B1 has several biochemical functions, for example, protein binding, signal transducer activity, signaling adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B1 itself. We selected most functions SH2B1 had, and list some proteins which have the same functions with SH2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MXI1;IL2RB;BCCIP;OAZ2;SYCP1;EPS8;XIAP;CLIC2;VIPAS39 |
| signal transducer activity | S1PR5A;MAPKAPK5;TAAR12F;OLFR488;TRAF2;PLCB3;AXIN1;RRH;GNB3 |
| signaling adaptor activity | AFAP1L2;LDLRAP1;SH2B3;GNB2L1;SH2B2;SH2B1;HOMER1;MPP7 |
SH2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B1.
EGFR; JAK2; Stat3; INSR; MET; STAT3; Stat3; KIAA0319
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