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SH2D2A

  • Official Full Name

    SH2 domain containing 2A

  • Overview

    This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants.
  • Synonyms

    SH2D2A; SH2 domain containing 2A; SH2 domain protein 2A; SH2 domain-containing protein 2A; F2771; T cell specific adapter protein TSAd; T cell specific adpater protein TSAd; T lymphocyte specific adaptor protein; TSAd; SCAP; SH2 domain containing adapter protein; SH2 domain containing protein 2A; T cell specific adapter protein; VEGF receptor associated protein; VRAP; VEGF receptor-associated protein;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SH2D2A-1878HCL Recombinant Human SH2D2A 293 Cell Lysate HEK293 N/A
Human SH2D2A-2002H Recombinant Human SH2D2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SH2D2A-1415HFL Recombinant Full Length Human SH2D2A Protein, C-Flag-tagged Mammalian cells Flag
Human SH2D2A-2002H-B Recombinant Human SH2D2A Protein Pre-coupled Magnetic Beads HEK293
Mouse Sh2d2a-5835M Recombinant Mouse Sh2d2a Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SH2D2A Related Articles
  • SH2D2A Related Research Area

SH2D2A involved in several pathways and played different roles in them. We selected most pathways SH2D2A participated on our site, such as VEGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
VEGF signaling pathwayPIK3CG;RAC3A;PTK2;BADB;RAF1B;SHC2;NRAS;MAPK11;RAC3B

SH2D2A has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D2A itself. We selected most functions SH2D2A had, and list some proteins which have the same functions with SH2D2A. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingUSP8;DRD4;DOCK1;ADAM15;DENND1A;ABI2;ELMO3;FUT8;DPYSL3
SH3/SH2 adaptor activityNCK1;SH2D3C;CHN2;SH3BGRL;CRKL;EPS8;LAT;GRB14;CHN1
protein bindingA2M;RNF11;MAT2A;ETV4;SAFB;PHLDA1;C2orf29;ZNF397;TEK

SH2D2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D2A here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D2A.

LCK; FSBP; PIK3R1; PTK2

Lee, H; Guo, J; et al. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. MOLECULAR AND CELLULAR BIOLOGY 18:5219-5228(1998).
Luttrell, LM; DellaRocca, GJ; et al. G beta gamma subunits Src-dependent phosphorylation of the epidermal growth factor receptor - A scaffold for G protein-coupled receptor-mediated Ras activation. JOURNAL OF BIOLOGICAL CHEMISTRY 272:4637-4644(1997).
PEREZ, L; URICH, M; et al. DOMAINS IN MIDDLE-T ANTIGEN THAT COOPERATE IN POLYOMAVIRUS-MEDIATED ONCOGENIC TRANSFORMATION. VIROLOGY 208:26-37(1995).
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