SH2D2A

Official Full Name

SH2 domain containing 2A
Overview

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants.
Synonyms

SH2D2A; SH2 domain containing 2A; SH2 domain protein 2A; SH2 domain-containing protein 2A; F2771; T cell specific adapter protein TSAd; T cell specific adpater protein TSAd; T lymphocyte specific adaptor protein; TSAd; SCAP; SH2 domain containing adapter protein; SH2 domain containing protein 2A; T cell specific adapter protein; VEGF receptor associated protein; VRAP; VEGF receptor-associated protein;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SH2D2A-1878HCL	Recombinant Human SH2D2A 293 Cell Lysate	HEK293	Non	Inquiry
Human	SH2D2A-2002H	Recombinant Human SH2D2A Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Human	SH2D2A-1415HFL	Recombinant Full Length Human SH2D2A Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	SH2D2A-2002H-B	Recombinant Human SH2D2A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	Sh2d2a-5835M	Recombinant Mouse Sh2d2a Protein, Myc/DDK-tagged	HEK293T	Myc&DDK	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SH2D2A involved in several pathways and played different roles in them. We selected most pathways SH2D2A participated on our site, such as VEGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
VEGF signaling pathway	MAP2K1;RAC1;AKT2;RAC3B;HSPB1;PLCG2;PLA2G4D;RAC1A;PPP3R1B

SH2D2A has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D2A itself. We selected most functions SH2D2A had, and list some proteins which have the same functions with SH2D2A. You can find most of the proteins on our site.

Function	Related Protein
SH3 domain binding	SH3BP2;PLSCR1;EFS;ITGB1BP2;KHDRBS1;RAD9A;SH3BP5LA;ADAM17;FUT8
SH3/SH2 adaptor activity	GAB1;SH2D3A;GRB14;SH2D1A;PTPN11;CHN2;SH3BP2;EPS8;SH3BGRL
protein binding	SUZ12;GP5;MAP4K4;FAM207A;KIAA1143;ZC3H12A;APBB1;C2orf28;DOCK10

SH2D2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D2A here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D2A.

LCK; FSBP; PIK3R1; PTK2

Research Area

Adaptor Proteins

Lee, H; Guo, J; et al. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. MOLECULAR AND CELLULAR BIOLOGY 18:5219-5228(1998).

Luttrell, LM; DellaRocca, GJ; et al. G beta gamma subunits Src-dependent phosphorylation of the epidermal growth factor receptor - A scaffold for G protein-coupled receptor-mediated Ras activation. JOURNAL OF BIOLOGICAL CHEMISTRY 272:4637-4644(1997).

PEREZ, L; URICH, M; et al. DOMAINS IN MIDDLE-T ANTIGEN THAT COOPERATE IN POLYOMAVIRUS-MEDIATED ONCOGENIC TRANSFORMATION. VIROLOGY 208:26-37(1995).