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Official Full Name SH3 domain containing ring finger 1
Background This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Synonyms SH3RF1; SH3 domain containing ring finger 1; SH3 multiple domains 2 , SH3MD2; E3 ubiquitin-protein ligase SH3RF1; KIAA1494; plenty of SH3 domains; POSH; RNF142; FLJ21602; Plenty of SH3s; Ring finger protein 142; RNF 142; SH3 domain containing RING finger protein 1; SH3 multiple domains 2; OTTHUMP00000219547; SH3 multiple domains protein 2; SH3 domain-containing RING finger protein 1; putative E3 ubiquitin-protein ligase SH3RF; SH3MD2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SH3RF1-1864HCL Recombinant Human SH3RF1 293 Cell Lysate HEK293 N/A
    Human SH3RF1-2652H Recombinant Human SH3RF1, GST-tagged E.coli GST
    Human SH3RF1-3097H Recombinant Human SH3RF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Sh3rf1-5851M Recombinant Mouse Sh3rf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SH3RF1-5382R Recombinant Rat SH3RF1 Protein Mammalian Cell His
    Zebrafish SH3RF1-3932Z Recombinant Zebrafish SH3RF1 Mammalian Cell His
    Zebrafish SH3RF1-4417Z Recombinant Zebrafish SH3RF1 Mammalian Cell His

    sh3rf1 involved in several pathways and played different roles in them. We selected most pathways sh3rf1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with sh3rf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System ITK; EGFR; TREML2; Mill2; ATG7; TRAT1; CMTM2A; HECTD3; KLHL21; MOV10
    Antigen processing: Ubiquitination &amp KLHL21; DZIP3; ASB9; LRR1; SPSB1; ASB2; RNF25; RNF34; UBE2U; SPSB2
    Proteasome degradation RNF19B; STUB1; TRIM50; LTN1; FBXO17; SPSB4; RNF4; WWP1; ASB3; TRIM41
    Class I MHC mediated antigen processing &amp TRIM11; RNF182; TRIM69; FBXO27; VPRBP; MKRN1; RNF19B; ASB4; BLMH; FCGR1B
    presentation CYBA; HECTD3; HUWE1; RNF25; ASB2; RNF4; TPP2; CD207; GAN; ASB14
    G13 Signaling Pathway DIAPH1; ARHGEF1A; CIT; TNK2; RTKN; MYBPH; GNA13; RHPN2; SH3RF1; MYL1
    Immune System CD300E; MKRN1; RBCK1; BTR09; DEFB116; KIF5A; PLD4; CYLD; MGC174857; TNFRSF13C

    sh3rf1 has several biochemical functions, for example, ligase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sh3rf1 itself. We selected most functions sh3rf1 had, and list some proteins which have the same functions with sh3rf1. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity AMFR; RFWD2; MID1; RNF144AA; FPGS; ZNRF2B; RNF213; SMURF1; GATB; PELI3
    protein binding SLX4; SMN1; WEE1; PPP2R1A; SPRY1; ZDHHC17; COL3A1; UPF1; ARF1; INTS12
    zinc ion binding TRIM28; MT2A; UMPS; RNF222; PHF23A; MID2; ERAP1; ISL2A; ZNFL1; Alb

    sh3rf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sh3rf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of sh3rf1.


    Kim, TW; Kang, YK; et al. SH3RF2 functions as an oncogene by mediating PAK4 protein stability. CARCINOGENESIS 35:624-634(2014).
    Karkkainen, S; van der Linden, M; et al. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. FEBS LETTERS 584:3867-3872(2010).

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