|Official Full Name||SH3 domain containing ring finger 1|
|Background||This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.|
|Synonyms||SH3RF1; SH3 domain containing ring finger 1; SH3 multiple domains 2 , SH3MD2; E3 ubiquitin-protein ligase SH3RF1; KIAA1494; plenty of SH3 domains; POSH; RNF142; FLJ21602; Plenty of SH3s; Ring finger protein 142; RNF 142; SH3 domain containing RING finger protein 1; SH3 multiple domains 2; OTTHUMP00000219547; SH3 multiple domains protein 2; SH3 domain-containing RING finger protein 1; putative E3 ubiquitin-protein ligase SH3RF; SH3MD2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
sh3rf1 involved in several pathways and played different roles in them. We selected most pathways sh3rf1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with sh3rf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||ITK; EGFR; TREML2; Mill2; ATG7; TRAT1; CMTM2A; HECTD3; KLHL21; MOV10|
|Antigen processing: Ubiquitination &||KLHL21; DZIP3; ASB9; LRR1; SPSB1; ASB2; RNF25; RNF34; UBE2U; SPSB2|
|Proteasome degradation||RNF19B; STUB1; TRIM50; LTN1; FBXO17; SPSB4; RNF4; WWP1; ASB3; TRIM41|
|Class I MHC mediated antigen processing &||TRIM11; RNF182; TRIM69; FBXO27; VPRBP; MKRN1; RNF19B; ASB4; BLMH; FCGR1B|
|presentation||CYBA; HECTD3; HUWE1; RNF25; ASB2; RNF4; TPP2; CD207; GAN; ASB14|
|G13 Signaling Pathway||DIAPH1; ARHGEF1A; CIT; TNK2; RTKN; MYBPH; GNA13; RHPN2; SH3RF1; MYL1|
|Immune System||CD300E; MKRN1; RBCK1; BTR09; DEFB116; KIF5A; PLD4; CYLD; MGC174857; TNFRSF13C|
sh3rf1 has several biochemical functions, for example, ligase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sh3rf1 itself. We selected most functions sh3rf1 had, and list some proteins which have the same functions with sh3rf1. You can find most of the proteins on our site.
|ligase activity||AMFR; RFWD2; MID1; RNF144AA; FPGS; ZNRF2B; RNF213; SMURF1; GATB; PELI3|
|protein binding||SLX4; SMN1; WEE1; PPP2R1A; SPRY1; ZDHHC17; COL3A1; UPF1; ARF1; INTS12|
|zinc ion binding||TRIM28; MT2A; UMPS; RNF222; PHF23A; MID2; ERAP1; ISL2A; ZNFL1; Alb|
sh3rf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sh3rf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of sh3rf1.
RAC1; SIAH2; AKT1; AKT2; UBC; PAK2; ADAM15; MAP4K3; SEMA6A; MYC; YWHAB