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Official Full Name SHC (Src homology 2 domain containing) transforming protein 3
Background SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.
Synonyms SHC3; SHC (Src homology 2 domain containing) transforming protein 3; src homology 2 domain containing transforming protein C3; SHC-transforming protein 3; N Shc; NSHC; SHCC; N-Shc; Neuronal Shc; Protein Rai; Rai; SH2 domain protein C3; SHC protein C; SHC-like protein, neuronal; SHC-transforming protein C; SHC3_HUMAN; Src homology 2 domain-containing transforming protein; Src homology 2 domain-containing-transforming protein C3; src homology 2 domain-containing transforming protein C3
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SHC3-1277H Recombinant Human SHC3 protein, His & GST-tagged E.coli His/GST
    Human SHC3-1602HCL Recombinant Human SHC3 cell lysate N/A
    Human SHC3-2655H Recombinant Human SHC3, GST-tagged E.coli GST
    Mouse SHC3-15092M Recombinant Mouse SHC3 Protein Mammalian Cell His
    Rhesus Macaque SHC3-4193R Recombinant Rhesus monkey SHC3 Protein, His-tagged Mammalian Cell His

    SHC3 involved in several pathways and played different roles in them. We selected most pathways SHC3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway AKT2L; PTK2AB; ERBB3; MAPK8B; AREGB; PIK3CA; NCK1; ERBB3B; PRKCA; CBLC
    Ras signaling pathway LAT; PRKACG; RAPGEF5; RASAL1; ABL1; PAK6; INS1; PLA2G2A; RASA1; MAP2K1
    Chemokine signaling pathway GNGT1; RAF1; GNG2; NCF1; CCR9; CCL19; VAV3; GNG10; WAS; PIK3CG
    Phospholipase D signaling pathway CYTH3; NRAS; GNAS; CXCR1; PLD1; GRM2; MAPK3; SHC4; AVPR2; DGKD
    Focal adhesion PIK3R1; ITGA7; ITGAV; THBS1; ITGA1; AKT3A; MYL12.1; THBS4B; SEPP1; CAPN2L
    Natural killer cell mediated cytotoxicity PPP3CC; PIK3CD; KLRD1; PIK3R5; IFNA6; MAP2K2; NFATC1; VAV3; PTPN6; SHC3
    Neurotrophin signaling pathway PLCG2; HRAS; MAP2K7; PIK3R2; MAP2K2; TP73; PIK3CG; MAGED1; NGFRAP1; SH2B2
    Insulin signaling pathway G6PC3; PRKAR2A; PIK3R1; SOCS3; PDPK1; G6PC2; MAPK9; PRKAG3B; TSC1; INPPL1
    Estrogen signaling pathway CREB3L3; MAPK3; CALM2; NOS3; CREB5; GNAI2; NRAS; PLCB1; GNAI1; PIK3CB
    Prolactin signaling pathway INS; SOCS6; MAPK3; PRL; MAPK8; SOCS3; GRB2; SHC3; LHB; RELA
    Alcoholism GM14479; HDAC5; SHC4; HIST1H3C; HIST1H2BM; CREB3L2; HIST1H3E; CALML5; PDYN; HAT1
    Bacterial invasion of epithelial cells ARPC5; RHOG; PIK3R1; ARPC4; SRC; CLTB; PXN; ILK; SEPT11; ELMO2
    Chronic myeloid leukemia RUNX1; TGFB1; MAP2K2; SHC3; RELA; PIK3CA; CBL; AKT1; PIK3R5; CDK6

    SHC3 has several biochemical functions, for example, protein binding, protein kinase binding, receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHC3 itself. We selected most functions SHC3 had, and list some proteins which have the same functions with SHC3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SERPINA1; CASC3; PIM2; RHOJ; EMP1; STMN2; USP47; FAM53C; GTF2A1; CCNA1
    protein kinase binding AGTR1A; ZBTB4; CCND2; CACNB4; SMAD1; PTPN6; SPRED1; CAV1; CNTLN; TRIM5
    receptor tyrosine kinase binding PTPN2; ANGPT4; GAS6; PTPN1; TOB1; SOCS5; DOCK4; FLT3LG; FNTA; SHC4
    signal transducer activity MIER1B; MRGPRA5; GHRHR2; PPM1A; TNK1; TAAR14E; AVPR2L; GNG10; MC5RA; GNG8

    SHC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHC3.


    Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).
    Adams, SJ; Aydin, IT; et al. GAB2-a Scaffolding Protein in Cancer. MOLECULAR CANCER RESEARCH 10:1265-1270(2012).

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