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Official Full Name SIN3 transcription regulator homolog A (yeast)
Background The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Synonyms SIN3A; SIN3 transcription regulator homolog A (yeast); SIN3 homolog A, transcription regulator (yeast); paired amphipathic helix protein Sin3a; DKFZP434K2235; KIAA0700; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; SIN3 homolog A, transcription regulator; histone deacetylase complex subunit Sin3a; FLJ90319
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIN3A-2676H Recombinant Human SIN3A, GST-tagged E.coli GST
    Mouse SIN3A-15141M Recombinant Mouse SIN3A Protein Mammalian Cell His
    Rhesus Macaque SIN3A-4205R Recombinant Rhesus monkey SIN3A Protein, His-tagged Mammalian Cell His
    Chicken SIN3A-5539C Recombinant Chicken SIN3A Mammalian Cell His

    sin3a involved in several pathways and played different roles in them. We selected most pathways sin3a participated on our site, such as Thyroid hormone signaling pathway, Huntingtons disease, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with sin3a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway TP53; HDAC2; CASP9; PIK3R5; NCOR1; MED13L; TRP53; SLC2A1; ACTB; TBC1D4
    Huntingtons disease NDUFB2; VDAC1; NDUFA4; ATP5C1; NRF1; NDUFS2; TBPL2; ATP5J; NDUFA13; COX4I1
    Transcriptional misregulation in cancer MLF1; SIX4; DDX5; HOXA10; MLL1; PER2; IL-8; RARA; EWSR1; CD40

    sin3a has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II repressing transcription factor binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by sin3a itself. We selected most functions sin3a had, and list some proteins which have the same functions with sin3a. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II activating transcription factor binding NFE2L2; EGR2; DUSP26; LDB1; SIN3A; EP300; BHLHE40; ATF2; BEX1; CREB1
    RNA polymerase II repressing transcription factor binding TBX5A; MTA1; BBS4; GTF2A2; BBS10; TCERG1; GATA6; BBS2; MKKS; RBPJ
    RNA polymerase II transcription corepressor activity OLIG3; SIN3B; TLE1; SIN3AA; TCERG1; CITED2; NFIB; RERE; TBX18; TBX15
    chromatin binding JARID2B; SIN3B; APBB1; ING2; RERE; RDBP; POLR3D; NKX6; MEIS1; HOXD13
    contributes_to histone deacetylase activity SIN3A; SALL1; SIN3AA; SUDS3; BRMS1LA; SIN3B; BRMS1; BRMS1L
    protein binding DDX17; TMEM74; WARS; PSMB4; PLLP; GAGE5; OCA2; IFNA2; PDIK1L; GPS1
    protein deacetylase activity HDAC1; HDAC10; HDAC2; HDAC9; SIN3A; HDAC5; SIRT1; HDAC4; HDAC3; SIRT2
    transcription factor activity, sequence-specific DNA binding BARX1; SALL1; TEAD3; Ar; E2F4; NR4A2A; GLI2; ELK4; SMAD3B; YBX1
    transcription regulatory region sequence-specific DNA binding ARNTL; BACH1B; NFE2; ZNF658; KCNA3; NFE2L1; NFE2L3; NFE2L2A; POU2F1; NR5A2

    sin3a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sin3a here. Most of them are supplied by our site. Hope this information will be useful for your research of sin3a.


    Sugimoto, T; Tomita, A; et al. Escape mechanisms from antibody therapy to lymphoma cells: Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390:48-53(2009).
    Zhao, X; Jankovic, V; et al. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. GENES & DEVELOPMENT 22:640-653(2008).

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