SIN3B

  • Official Full Name

    SIN3 transcription regulator homolog B
  • Overview

    Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.
  • Synonyms

    SIN3B;SIN3 transcription regulator homolog B (yeast);SIN3 homolog B, transcription regulator (yeast);paired amphipathic helix protein Sin3b;KIAA0700;transcriptional corepressor Sin3b;SIN3 homolog B, transcription regulator;SIN3 homolog B, transcrip
Cat.# Product name Source (Host) Species Tag Protein Length Price
SIN3B-4043Z Recombinant Zebrafish SIN3B Mammalian Cells Zebrafish His
SIN3B-1606HCL Recombinant Human SIN3B cell lysate Human Non

    Involved Pathway

    SIN3B involved in several pathways and played different roles in them. We selected most pathways SIN3B participated on our site, such as Epigenetic regulation of gene expression,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIN3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression ZNF350,IPO8,D1BWG0212E,NSUN2,POLR3F,CHD4,RRAGB,NR1D2B,ZNF583,COX18
    Metabolism STAB2,AHCY,OAZ2,DECR1,MED9,GNG13B,FAAH2B,CIAPIN1,CYP24A1,CYP2B6
    NoRC negatively regulates rRNA expression CD3EAP,SAP30L,SAP30BP,BAZ2A,TAF1D,DNMT1,TAF1B,TAF1A,SAP130,TAF1C
    Hedgehog signaling events mediated by Gli proteins LGALS3,SPOP,KIF3A,SAP18,SAP30,CSNK1G3,CSNK1G2,IFT88,MTSS1
    Negative epigenetic regulation of rRNA expression SAP18,CD3EAP,TAF1B,DNMT1,SAP30L,SAP130,SAP30BP,DNMT3B,BAZ2A,RRP8
    Epigenetic regulation of gene expression DNMT3A,JARID2,TET1,SAP30BP,DNMT1,SAP130,SUDS3,CD3EAP,SMARCA5,AEBP2
    Fatty acid, triacylglycerol, and ketone body metabolism PPARGC1B,AGPAT1,CTGF,DECR1,THEM5,MED26,PLIN2,STIL,GRHL1,MED19
    Metabolism of lipids and lipoproteins APOA4A,CPT2,BRSK2,CERS4A,ACOT7,MED25,APOEA,CSNK1G2,FAAH2,CPTP

    Protein Function

    SIN3B has several biochemical functions, for example, RNA polymerase II transcription corepressor activity,chromatin binding,contributes_to histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIN3B itself. We selected most functions SIN3B had, and list some proteins which have the same functions with SIN3B. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to histone deacetylase activity SIN3AA,SUDS3,SALL1,BRMS1L,BRMS1LA,SIN3A,BRMS1
    protein binding JUP,RPS6KA4,NEDD9,NMB,HNRNPA1,ZNF398,UCHL1,SMO,GTF2I,MICA
    RNA polymerase II transcription corepressor activity URI1,SIN3AA,UXT,TCERG1,CTBP1,N4BP2L2,TLE1,OLIG3,RBBP8,BEND6
    chromatin binding JMJD5,GABPA,SSRP1A,JUB,Ar,ARID3C,NSBP1,NR5A1B,KLHDC3,MSH6

    Interacting Protein

    SIN3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIN3B here. Most of them are supplied by our site. Hope this information will be useful for your research of SIN3B.

    HDAC1;MYC;HDAC2;HCFC1;MXD1;PPP1CC;collagen sequence;mdm2_human_probe;pyr1_human_gene;hes1_human_gene;NCL

    Resources

    References

    • Nishibuchi, G; Shibata, Y; et al. Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 289:28956-28970(2014).
    • Li, YL; Choi, PS; et al. MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State. CANCER CELL 26:262-272(2014).

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