|Official Full Name||SIX homeobox 3|
|Background||This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.|
|Synonyms||SIX3; SIX homeobox 3; holoprosencephaly 2, alobar or semilobar , HPE2, sine oculis homeobox homolog 3 (Drosophila); homeobox protein SIX3; Sine oculis homeobox homolog 3; SIX3_HUMAN; OTTHUMP00000201650; HPE2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
six3 involved in several pathways and played different roles in them. We selected most pathways six3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with six3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
six3 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, histone deacetylase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six3 itself. We selected most functions six3 had, and list some proteins which have the same functions with six3. You can find most of the proteins on our site.
|RNA polymerase II distal enhancer sequence-specific DNA binding||PROP1; NR1H4; HOXB5; MEOX2; H3F3B; H3F3A; BACH2; NFATC1; NFE2L1; HNRNPC|
|histone deacetylase binding||USF1; RAD9; CEBPB; NCOR2; MECP2; TOP2B; MEF2A; XBP1; HES1; MEF2B|
|protein binding||FRMD7; YAF2; TRMT112; RARA; DNAI1; C10orf137; ARHGEF6; AZIN1; WIBG; ANKRD32|
|transcription coactivator activity||RFXAP; KAT5; SUPT3H; ASXL1; CTBP2; TGFB1I1; UTF1; ATF6; YAP1; ARL2BP|
|transcription corepressor binding||FAM89B; RORA; HDGF; NR1D1; SIX3|
|transcription factor activity, sequence-specific DNA binding||POU3F2B; MSRB2; ZNF334; RAB11FIP4A; NFIC; ZNF383; FOXO3B; ZFP641; NR1D1; SLAMF7|
|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding||PROP1; SUB1; NFATC1; SFPI1; NFE2L1; HMGA1; TARDBP; FOXH1; ZEB2; BACH1|
six3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six3 here. Most of them are supplied by our site. Hope this information will be useful for your research of six3.