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SIX3

Official Full Name

SIX homeobox 3
Overview

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
Synonyms

SIX3; SIX homeobox 3; holoprosencephaly 2, alobar or semilobar , HPE2, sine oculis homeobox homolog 3 (Drosophila); homeobox protein SIX3; Sine oculis homeobox homolog 3; SIX3_HUMAN; OTTHUMP00000201650; HPE2;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SIX3-1823HCL	Recombinant Human SIX3 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	SIX3-15163M	Recombinant Mouse SIX3 Protein	Mammalian Cell	His	Inquiry
Mouse	SIX3-8187M-B	Recombinant Mouse SIX3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	SIX3-8187M	Recombinant Mouse SIX3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Chicken	SIX3-5935C	Recombinant Chicken SIX3	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

SIX3 involved in several pathways and played different roles in them. We selected most pathways SIX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SIX3 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, histone deacetylase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX3 itself. We selected most functions SIX3 had, and list some proteins which have the same functions with SIX3. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II distal enhancer sequence-specific DNA binding	T;CDX2;NFE2L1;NFE2L2;BACH1A;BACH1;H2AFZ;SOX10;JUN
histone deacetylase binding	RFXANK;KAT2B;HDAC9;PHB;SP2;BRMS1;HOXA10;NR2E1;ZNHIT1
protein binding	DNER;MRPL45;PRPS2;SCRN2;FAM156A;SERPINB9;RGS3;DYNC1H1;FLNA
transcription coactivator activity	CITED2;CTBP2;ACTL6B;DDX17;TFDP1;SMARCA2;LPIN1;RAP2C;RBPMS
transcription corepressor binding	NR1D1;SIX3;HDGF;FAM89B;RORA
transcription factor activity, sequence-specific DNA binding	FOSL1;E2F8;NKX6-1;CSDA;NANOG;FOXQ2;ZNF43;ZFP30;ZNF583
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	FOXH1;CDX1;SPI1;HMGA1;HOXB5;SFPI1;PROP1;POU4F1;NFKB1

SIX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX3.