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Official Full Name SIX homeobox 3
Background This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
Synonyms SIX3; SIX homeobox 3; holoprosencephaly 2, alobar or semilobar , HPE2, sine oculis homeobox homolog 3 (Drosophila); homeobox protein SIX3; Sine oculis homeobox homolog 3; SIX3_HUMAN; OTTHUMP00000201650; HPE2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIX3-1823HCL Recombinant Human SIX3 293 Cell Lysate HEK293 N/A
    Mouse SIX3-15163M Recombinant Mouse SIX3 Protein Mammalian Cell His
    Chicken SIX3-5935C Recombinant Chicken SIX3 Mammalian Cell His

    six3 involved in several pathways and played different roles in them. We selected most pathways six3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with six3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    six3 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, histone deacetylase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six3 itself. We selected most functions six3 had, and list some proteins which have the same functions with six3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding PROP1; NR1H4; HOXB5; MEOX2; H3F3B; H3F3A; BACH2; NFATC1; NFE2L1; HNRNPC
    histone deacetylase binding USF1; RAD9; CEBPB; NCOR2; MECP2; TOP2B; MEF2A; XBP1; HES1; MEF2B
    protein binding FRMD7; YAF2; TRMT112; RARA; DNAI1; C10orf137; ARHGEF6; AZIN1; WIBG; ANKRD32
    transcription coactivator activity RFXAP; KAT5; SUPT3H; ASXL1; CTBP2; TGFB1I1; UTF1; ATF6; YAP1; ARL2BP
    transcription corepressor binding FAM89B; RORA; HDGF; NR1D1; SIX3
    transcription factor activity, sequence-specific DNA binding POU3F2B; MSRB2; ZNF334; RAB11FIP4A; NFIC; ZNF383; FOXO3B; ZFP641; NR1D1; SLAMF7
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding PROP1; SUB1; NFATC1; SFPI1; NFE2L1; HMGA1; TARDBP; FOXH1; ZEB2; BACH1

    six3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six3 here. Most of them are supplied by our site. Hope this information will be useful for your research of six3.

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