|Official Full Name||SIX homeobox 4|
|Background||This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.|
|Synonyms||SIX4; SIX homeobox 4; sine oculis homeobox (Drosophila) homolog 4 , sine oculis homeobox homolog 4 (Drosophila); homeobox protein SIX4; AREC3; sine oculis homeobox homolog 4; MGC119450; MGC119452; MGC119453|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
six4 involved in several pathways and played different roles in them. We selected most pathways six4 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with six4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Transcriptional misregulation in cancer||PAX3; LMO2; FEV; DDX5; EWSR1; CCNT2; IL1R2; RUNX2; SIX1; IGF1R|
six4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six4 itself. We selected most functions six4 had, and list some proteins which have the same functions with six4. You can find most of the proteins on our site.
|DNA binding||ZNF471; ZNF83; ZKSCAN5; ZNF823; LIN54; ISL2B; ZNF326; RC3H2; FOXL2; TFDP1A|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||PER1; MITFA; HNRNPK; JDP2; FOXL2; MAX; MED1; NFAT5; TBX20; T|
|protein binding||RNF138; FAM161A; DDX31; CTAGE5; LINGO1B; GPR19; STXBP3; ELMO3; STX8; CYHR1|
|sequence-specific DNA binding||TEF; HOXC13B; RXRBB; ZFP536; ETS1; HOXA11A; DMRT3A; SIX1; NR6A1A; DMBX1A|
|transcription factor activity, sequence-specific DNA binding||POU2F1B; MNX1; PFDN1; ZFP146; ZFP260; SCML1; SMAD3; ZNF35; NR2C2; HMGB1|
|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding||OTX2; HNF1A; NOBOX; ZFAT; PLAG1; MESP1; ONECUT1; HIF1A; NFKB2; PGR|
six4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six4 here. Most of them are supplied by our site. Hope this information will be useful for your research of six4.