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Official Full Name SIX homeobox 4
Background This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.
Synonyms SIX4; SIX homeobox 4; sine oculis homeobox (Drosophila) homolog 4 , sine oculis homeobox homolog 4 (Drosophila); homeobox protein SIX4; AREC3; sine oculis homeobox homolog 4; MGC119450; MGC119452; MGC119453
    • Species :
    • Mouse
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse SIX4-15164M Recombinant Mouse SIX4 Protein Mammalian Cell His

    six4 involved in several pathways and played different roles in them. We selected most pathways six4 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with six4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer PAX3; LMO2; FEV; DDX5; EWSR1; CCNT2; IL1R2; RUNX2; SIX1; IGF1R

    six4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six4 itself. We selected most functions six4 had, and list some proteins which have the same functions with six4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZNF471; ZNF83; ZKSCAN5; ZNF823; LIN54; ISL2B; ZNF326; RC3H2; FOXL2; TFDP1A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding PER1; MITFA; HNRNPK; JDP2; FOXL2; MAX; MED1; NFAT5; TBX20; T
    protein binding RNF138; FAM161A; DDX31; CTAGE5; LINGO1B; GPR19; STXBP3; ELMO3; STX8; CYHR1
    sequence-specific DNA binding TEF; HOXC13B; RXRBB; ZFP536; ETS1; HOXA11A; DMRT3A; SIX1; NR6A1A; DMBX1A
    transcription factor activity, sequence-specific DNA binding POU2F1B; MNX1; PFDN1; ZFP146; ZFP260; SCML1; SMAD3; ZNF35; NR2C2; HMGB1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding OTX2; HNF1A; NOBOX; ZFAT; PLAG1; MESP1; ONECUT1; HIF1A; NFKB2; PGR

    six4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six4 here. Most of them are supplied by our site. Hope this information will be useful for your research of six4.

    Kdm6a; Eya2

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