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Official Full Name SIX homeobox 5
Background The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.
Synonyms SIX5; SIX homeobox 5; DMAHP, sine oculis homeobox (Drosophila) homolog 5 , sine oculis homeobox homolog 5 (Drosophila); homeobox protein SIX5; sine oculis homeobox homolog 5; DM locus-associated homeodomain protein; dystrophia myotonica-associated homeo
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIX5-1822HCL Recombinant Human SIX5 293 Cell Lysate HEK293 N/A
    Mouse SIX5-15165M Recombinant Mouse SIX5 Protein Mammalian Cell His
    Rhesus Macaque SIX5-4210R Recombinant Rhesus monkey SIX5 Protein, His-tagged Mammalian Cell His
    Zebrafish SIX5-9241Z Recombinant Zebrafish SIX5 Mammalian Cell His

    six5 involved in several pathways and played different roles in them. We selected most pathways six5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with six5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    six5 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six5 itself. We selected most functions six5 had, and list some proteins which have the same functions with six5. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NKX2-5; NKX6; PHOX2B; NFAT5; TBX3; HOXA5; ZNF543; MEOX2; MZF1; GLI3
    protein binding DUSP15; GABBR1; TXNDC11; RHOJ; PAK6; PIN4; PCBD1; TLR6; MLKL; RABGGTB

    six5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six5 here. Most of them are supplied by our site. Hope this information will be useful for your research of six5.

    ATXN1; q81y32_bacan; hemC; degQ

    Pham, YCN; Man, NT; et al. Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies. JOURNAL OF CELLULAR BIOCHEMISTRY 95:990-1001(2005).
    Man, NT; Pham, YCN; et al. Nuclear localization of the myotonic dystrophy-associated Six5 protein using a new panel of monoclonal antibodies. JOURNAL OF THE NEUROLOGICAL SCIENCES 199:S5-S5(2002).
    Lam, LT; Pham, YCN; et al. Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. HUMAN MOLECULAR GENETICS 9:2167-2173(2000).
    Ohto, H; Takizawa, T; et al. Tissue and developmental distribution of Six family gene products. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 42:141-148(1998).

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