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Official Full Name SIX homeobox 6
Background The protein encoded by this gene is a homeobox protein that is similar to the Drosophila sine oculis gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
Synonyms SIX6; SIX homeobox 6; OPTX2, sine oculis homeobox (Drosophila) homolog 6 , sine oculis homeobox homolog 6 (Drosophila); homeobox protein SIX6; Six9; optic homeobox 2; homeodomain protein OPTX2; sine oculis homeobox homolog 6; OPTX2; MCOPCT2
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIX6-1821HCL Recombinant Human SIX6 293 Cell Lysate HEK293 N/A
    Human SIX6-7190H Recombinant Human SIX Homeobox 6, His-tagged E.coli His
    Chicken SIX6-6552C Recombinant Chicken SIX6 Mammalian Cell His

    six6 involved in several pathways and played different roles in them. We selected most pathways six6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with six6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    six6 has several biochemical functions, for example, DNA binding, transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six6 itself. We selected most functions six6 had, and list some proteins which have the same functions with six6. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding DNMT3A; GM6026; MSXC; VDR; ZNF565; MXTX2; AIFM1; HIST1H2AG; HNF1BB; TEAD1
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding SIX6; SUB1; SIX3; PROP1; SPI1; HMGA1; MIXL1; REL; ARID3B; NFE2L1

    six6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six6 here. Most of them are supplied by our site. Hope this information will be useful for your research of six6.

    Mabuchi, F; Sakurada, Y; et al. Involvement of Genetic Variants Associated With Primary Open-Angle Glaucoma in Pathogenic Mechanisms and Family History of Glaucoma. AMERICAN JOURNAL OF OPHTHALMOLOGY 159:437-444(2015).
    Williams, SEI; Carmichael, TR; et al. The Genetics of POAG in Black South Africans: A Candidate Gene Association Study. SCIENTIFIC REPORTS 5:-(2015).

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