SKI

  • Official Full Name

    v-ski avian sarcoma viral oncogene homolog
  • Overview

    This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
  • Synonyms

    SKI;v-ski avian sarcoma viral oncogene homolog;SGS;SKV;ski oncogene;ski oncoprotein;proto-oncogene c-Ski
Cat.# Product name Source (Host) Species Tag Protein Length Price
SKI-3376C Recombinant Chicken SKI Mammalian Cells Chicken His
SKI-1815HCL Recombinant Human SKI 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling,C-MYB transcription factor network,Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog signaling pathway GLI2,PRKACAB,PTCH1,WNT2BA,GLI2A,WNT1,PRKACG,PRKACA,WNT10B,GSK3B
    Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD3B,USP9X,TRIM33,SKIB,RNF111,PARP1,SKILB,USP9,SKIA
    BMP receptor signaling NOG,SOSTDC1,CHRDL1,CTDSPL,AHSG,FST,HFE2,RGMB,GREM1,CTDSP2
    Signal Transduction OR10A5,RBP2A,KREMEN2,S1PR5B,ARHGEF25,APOA4B.2,KDM4C,PYGO1,ADCYAP1B,CDH5
    C-MYB transcription factor network CSF1R,CEBPB,COL1A2,SMARCA2,ELANE,CREBBP,PTCRA,CDK6,TRIM28,GATA1
    Regulation of nuclear SMAD2/3 signaling CBFB,GSC,FOXH1,CITED1,NKX2,SNIP1,MYOD1
    Gene Expression PPARAA,METTL1,ZNF468,DCP1B,SUDS3,TAF1A,ZNF839,TRMT6,ZKSCAN1,TAF1D
    Generic Transcription Pathway ZNF23,ZNF664,ZNF554,TEAD1A,NR2E1,ZNF10,ZNF202,GPR19,ZNF2,ZNF606

    Protein Function

    SKI has several biochemical functions, for example, SMAD binding,chromatin binding,histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding SMARCD1,MEIOB,LDB1,TOX2,CCNT1,Ar,KDM5A,RNF168,ATRX,PHF8
    protein binding C9orf116,GZMM,IL-8,UNC45B,FLT4,NIPA2,BICC1,KIAA0141,RNF180,RAB11FIP2
    ubiquitin protein ligase binding TRAF5,GPR19,OTUB1,CUL1,SMC6,SLC25A5,VCL,CASP10,RAD18,UBOX5
    protein domain specific binding STAMBP,YWHABA,ARFIP2A,DRD3,ARL1,CHMP2A,VRK2,NEDD4,ODF1,DDC
    SMAD binding FKBP1A,BMPR1B,HMGA2,YY1,RNF111,TGFBRAP1,PRDM16,EP300,SKOR1A,SKOR1B
    transcription corepressor activity ANKRD1,HSF4,TBL1XR1A,DMAP1,RCOR2,BCOR,SSX2,HOXC6,DDX54,AEBP1
    histone deacetylase inhibitor activity UCN
    repressing transcription factor binding RELA,MAGEA2,MAGEA2B,PRDM5,SRI,TBP,HDAC7,PARK7,RUNX2,NFYB
    protein kinase binding SPRED2,LIPE,PPP1R12B,CCNE1,AGTR1A,PLK1S1,PTPRR,TP73,PTPN2,DNAJA3

    Interacting Protein

    SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.

    SMAD3;SMAD4

    Resources

    References

    • Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
    • Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).

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