SKI

  • Official Full Name

    v-ski avian sarcoma viral oncogene homolog
  • Overview

    This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
  • Synonyms

    SKI;v-ski avian sarcoma viral oncogene homolog;SGS;SKV;ski oncogene;ski oncoprotein;proto-oncogene c-Ski
Cat.# Product name Source (Host) Species Tag Protein Length Price
SKI-3376C Recombinant Chicken SKI Mammalian Cells Chicken His
SKI-1815HCL Recombinant Human SKI 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling,C-MYB transcription factor network,Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network CREBBP,CBX4,GATA1,CDK6,MYC,ELANE,MYOD1,YEATS4,TOM1,CDKN1B
    BMP receptor signaling FST,CTDSP2,NOG,GREM1,RGMB,HFE2,CTDSPL,SOSTDC1,RGMA,CHRDL1
    Generic Transcription Pathway RXRBB,ESR2A,ZNF705A,ZNF785,ZFP37,ZNF19,NR5A1,ZNF234,RRAGB,COX6B1
    Downregulation of SMAD2/3:SMAD4 transcriptional activity RNF111,SKIB,USP9X,SMAD3B,USP9,SKILB,PARP1,SKIA,TRIM33
    Regulation of nuclear SMAD2/3 signaling SNIP1,NKX2,GSC,CITED1,MYOD1,CBFB,FOXH1
    Signal Transduction DLC1,RBP4,KAL1A,CRABP2,PRLH,RCA2.1,NMT1A,PTGDR2,DHRS3,ARHGEF25
    Hedgehog signaling pathway WNT1,STK36,PTCH2,BMP4,GSK3B,PRKACAB,WNT10B,WNT8B,CSNK1G2B,LRP2A
    Gene Expression SPCS3,ZNF707,SF3B2,ZNF114,NR1I3,KHSRP,NRBP1,BRF1B,ZNF773,EEF1B2

    Protein Function

    SKI has several biochemical functions, for example, SMAD binding,chromatin binding,histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.

    Function Related Protein
    repressing transcription factor binding MAGEA2,TBP,NOC2L,HDAC1,HDAC9,HDAC5,DDX20,CTBP1,PARK7,NFYB
    transcription corepressor activity ARHGAP35,APEX1,PSMC3,ALX1,TBL1XR1A,SSX5,NFIL3,SKOR2,TRIM28,DR1
    zinc ion binding ZDHHC15B,RABGGTB,LHX2A,OTUD7B,CSRP1B,TRIM35-39,CSRP3,MMP10,C6AST4,ARIH1L
    ubiquitin protein ligase binding UBE2NA,CUL1B,UBE2V1,PIAS4,EGR2,MAP1LC3B,CDC34A,UBE2G1B,PDE4D,MC4R
    histone deacetylase inhibitor activity UCN
    protein kinase binding CCND3,KIF13B,SKAP1,TRAF2,FOXO3,NEK9,HCLS1,CALM,NIPAL1,CCNA2
    protein domain specific binding TJP1,HIST1H4C,CNTROB,CNTLN,PKD1,GABRR2,ETV6,TNFAIP1,HIST2H4,AKAP5
    protein binding ATG13,COPS7A,ATG101,SHC4,TCF7L2,ZNF460,GTF2H4,MRPL41,PSMB5,POLRMT
    SMAD binding ACVR1B,SKILB,HIPK2,FLNA,TGFBR1,EP300,SKOR2,EID2,SKOR1,BMP2

    Interacting Protein

    SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.

    SMAD3;SMAD4

    Resources

    References

    • Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
    • Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).

    Ask a Question for All SKI Products

    Required fields are marked with *

    My Review for All SKI Products

    Required fields are marked with *