|Official Full Name||SMAD family member 1|
|Background||The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]|
|Synonyms||SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TGF-beta signaling pathway||BAMBIA; TGFB1; AMH; BMPR1A; RPS6KB1; TFDP1; GDF6; ID4; ACVR1BA; SMURF2|
|Hippo signaling pathway||PPP2R2B; CTGF; TGFBR2; TCF7L2; DLG1; LLGL1; TP73; BTRC; PPP2CB; BIRC5|
|Signaling pathways regulating pluripotency of stem cells||GRB2; INHBE; DLX5; HAND1; PAX6; WNT4; JARID2; WNT3A; PCGF1; FZD3|
|Transcriptional misregulation in cancer||MYCN; SUPT3H; CD14; TMPRSS2; FLI1; GOLPH3L; PML; PRCC; ZBTB16; IL-8|
SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.
|I-SMAD binding||SMURF1; SMAD7; SMAD6; AXIN2; TGFB1I1; SMAD2; SMAD1; SMAD4; TGFBR1; AXIN1|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||DPF2; PGR; CC2D1A; ZGPAT; IRF4; CTCFL; HHEX; ZNF114; ELF4; RFX1|
|RNA polymerase II core promoter sequence-specific DNA binding||H2AFY; RUVBL2; GATA6; TFAP2B; TBR1; NR4A2; H2AFZ; NSD1; SP3; STAT5A|
|co-SMAD binding||GATA4; SMAD6; USP9X; TGIF1; SMAD2; TRIM33; SMAD3; CITED1; SMAD1; FOXH1|
|identical protein binding||NDE1; C10orf88; PIP4K2C; PRC1; KCNRG; COL2A1; PAFAH1B3; MCM10; SMAD1; TRIP13|
|metal ion binding||HECTD1; ZFP1; ASPA; TSHZ1; WT1B; BCL11A; Scd2; CLCA1; MMP25; CHORDC1|
|protein binding||RAB7; SYCE1; C22orf39; S100A2; WARS; NAV2; HOXD12; COQ9; AP1M1; MPP2|
|protein heterodimerization activity||SMAD1; TAF9; CD3G; MEF2A; SDCBP; SPTAN1; RARA; HIST1H2BI; KCNH5; UGT1A6B|
|protein homodimerization activity||MITD1; GNPTG; VIL1; RPL7; APOE; ASNSD1; DMRTC1C2; NETO2; GSTZ1; NBL1|
|protein kinase binding||PTPN23; THY1; CCNB1; CD4; RPTOR; RAB11FIP2; HDAC4; NME2; NGFRAP1; MAPT|
|receptor signaling protein activity||NGF; CD3E; IL4R; TRAIP; CD19; RAF1B; TYROBP; NCR1; ARAF; cgr2b|
|transcription factor activity, sequence-specific DNA binding||SREBF1; T; ZC3H8; FOXP3A; HDAC1; PRDM1; DMRT3A; FOXJ1B; PRDM1A; ZNF16|
|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding||NR6A1; PLAG1; CTCFL; HOXA7; FOXC2; TFAP2B; MESP1; MYOCD; NEUROD6; GATA3|
|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity||SMAD9; SMAD1; SMAD2; SMAD3|
SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.
SMAD4; GSK3B; AR
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