SMAD1

  • Official Full Name

    SMAD family member 1

  • Overview

    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Synonyms

    SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD1-43H Recombinant Human SMAD1 protein, GST-tagged E.coli GST
Human SMAD1-30445TH Recombinant Human SMAD1 E.coli N/A
Human SMAD1-1092H Recombinant Human SMAD Family Member 1, GST-tagged E.coli GST
Human SMAD1-11H Recombinant Human SMAD1, His-tagged E.coli His
Human SMAD1-2799H Recombinant Human SMAD1, GST-tagged E.coli GST
Human SMAD1-160H Recombinant Human SMAD1 Protein, His-tagged E.coli His
Human SMAD1-12H Recombinant Human SMAD1, MYC/DDK-tagged HEK293 Myc/DDK
Human SMAD1-161H Recombinant Human SMAD1 Protein, His-tagged E.coli His
Human SMAD1-1677HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
Human SMAD1-1678HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
Human SMAD1-333H Recombinant Human SMAD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SMAD1-1916H Recombinant Human SMAD1 Protein, His-tagged E.coli His
Human SMAD1-4856HFL Recombinant Full Length Human SMAD1, Flag-tagged Mamanlian cells Flag
Human SMAD1-5865H Recombinant Human SMAD1 Protein (Asp259-Ser462), N-His tagged E.coli N-His
Human SMAD1-6690HF Active Recombinant Full Length Human SMAD1 Protein, GST-tagged E.coli GST
Human SMAD1-106HFL Recombinant Full Length Human SMAD1 Protein, N-His-tagged E.coli His
Mouse Smad1-657M Recombinant Mouse Smad1 protein, His & T7-tagged E.coli His/T7
Mouse SMAD1-15584M Recombinant Mouse SMAD1 Protein Mammalian Cell His
Mouse SMAD1-8456M Recombinant Mouse SMAD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Smad1-5949M Recombinant Mouse Smad1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SMAD1-8456M-B Recombinant Mouse SMAD1 Protein Pre-coupled Magnetic Beads HEK293
Rat Smad1-658R Recombinant Rat Smad1 protein, His-tagged E.coli His
Cattle SMAD1-656C Recombinant Cattle SMAD1 protein, His & T7-tagged E.coli His/T7
Rhesus Macaque SMAD1-4329R Recombinant Rhesus monkey SMAD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SMAD1-4145R Recombinant Rhesus Macaque SMAD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SMAD1-4145R-B Recombinant Rhesus Macaque SMAD1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SMAD1-8936Z Recombinant Zebrafish SMAD1 Mammalian Cell His
Chicken SMAD1-4493C Recombinant Chicken SMAD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMAD1 Related Articles
  • SMAD1 Related Gene Family
  • SMAD1 Related Research Area
  • SMAD1 Related Signal Pathway

SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayLEFTY2;SMAD3A;TGFB2;BMP2;BMPR2;FST;BMPR1BB;RHOA;ACVR2B
Hippo signaling pathwayNKD1;BMP7;CRB2;LATS2;AMH;PRKCI;BMPR1B;PPP2R1B;WTIP
Signaling pathways regulating pluripotency of stem cellsAPC;TBX3;PIK3R2;HRAS;FZD3;ID3;WNT2;LHX5;SMAD4
Transcriptional misregulation in cancerFUT8;ATF1;PDGFA;FOXO1;SFPI1;HDAC1;IL2RB;HIST1H3G;SS18

SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.

Function Related Protein
I-SMAD bindingSMAD2;AXIN2;SMAD4;TGFBR1;SMAD7;TGFB1I1;CTNNB1;SMAD6;SMAD1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingPATZ1;MYF6;ATOH1;KDM6A;TBX20;POU4F2;NKX6-1;PBX1;ATF7
RNA polymerase II core promoter sequence-specific DNA bindingNR4A2;PAX8;EP300;EGR1;TFAP2A;NSD1;TRP53;ZFP335;SP1
co-SMAD bindingSMAD3;CITED1;TRIM33;FOXH1;SMAD1;GATA4;TGIF1;USP9X;SMAD2
identical protein bindingSTAT6;GAPDH;PLDN;PSMA7;ERBB3;RALYL;C1QTNF9;MYOM1;ALDOA
metal ion bindingIDI2;STAMBPL1;MIPEP;STS;PRKAA1;VSNL1A;TIMM8B;NDUFS1;FTR43
protein bindingLRRC25;C9orf24;HIST2H4;SETD6;CDCA7L;SOX10;DMPK;CPT1B;NSUN4
protein heterodimerization activityERBB3;TCF4;H3F3B.1;MTTP;KCNN1;TLR1;H2-AA;Fzd4;TGFB1
protein homodimerization activityVPS25;ERN1;CBX1;BCL2L1;UGT1A6A;MAP3K5;ZBTB1;Bcl2a1b;IL6R
protein kinase bindingCHRNA7;CCNL1B;EEF2;EMP2;PPP1CB;ATP1A1;FZD5;CALM3;CAV2
receptor signaling protein activityRGS12B;PLCG1;FLRT2;DOK2;RGS14A;KLK1B3;FLRT1;DOK1;DCLK1
transcription factor activity, sequence-specific DNA bindingZFP322A;CLOCKB;MYT1LA;RBPJ;ZBTB14;FOXJ1B;ZIC5;RORAA;FOS
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTRP63;NPAS4;TP73;EHF;HOXA10;EPAS1;NFIA;ZNF750;SOX11
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activitySMAD1;SMAD2;SMAD9;SMAD3

SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.

SMAD4; GSK3B; AR

Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).
TGF
  • Q&As
  • Reviews

Q&As (5)

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What technologies are commonly used to study the expression and activity of SMAD1 in clinical research? 04/12/2023

Techniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.

How might targeting SMAD1 have implications for anti-cancer therapies? 07/05/2022

Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.

Are there any known genetic mutations in the SMAD1 gene associated with human diseases? 03/28/2021

Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.

How does SMAD1 interact with other proteins in the TGF-β pathway? 01/08/2020

SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.

How can SMAD1 be targeted for therapeutic interventions in bone-related disorders? 12/31/2019

Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.

Customer Reviews (3)

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Reviews
06/08/2022

    Whether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.

    08/08/2021

      This versatility allows me to explore different aspects of my research with confidence and accuracy.

      05/02/2018

        The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.

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