SMAD1 Protein


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Official Full Name SMAD family member 1
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Synonyms SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD1-1092H Recombinant Human SMAD Family Member 1, GST-tagged E.coli GST
    Human SMAD1-11H Recombinant Human SMAD1, His-tagged E.coli His
    Human SMAD1-12H Recombinant Human SMAD1, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD1-160H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-161H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-1677HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
    Human SMAD1-1678HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
    Human SMAD1-1916H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-2799H Recombinant Human SMAD1, GST-tagged E.coli GST
    Human SMAD1-30445TH Recombinant Human SMAD1 E.coli N/A
    Human SMAD1-333H Recombinant Human SMAD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human SMAD1-43H Recombinant Human SMAD1 protein, GST-tagged E.coli GST
    Mouse SMAD1-15584M Recombinant Mouse SMAD1 Protein Mammalian Cell His
    Mouse Smad1-5949M Recombinant Mouse Smad1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Smad1-657M Recombinant Mouse Smad1 protein, His & T7-tagged E.coli His/T7
    Rat Smad1-658R Recombinant Rat Smad1 protein, His-tagged E.coli His
    Rhesus Macaque SMAD1-4329R Recombinant Rhesus monkey SMAD1 Protein, His-tagged Mammalian Cell His
    Chicken SMAD1-4493C Recombinant Chicken SMAD1 Mammalian Cell His
    Zebrafish SMAD1-8936Z Recombinant Zebrafish SMAD1 Mammalian Cell His
    Cattle SMAD1-656C Recombinant Cattle SMAD1 protein, His & T7-tagged E.coli His/T7

    SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway LFT1; SMAD9; TGFBR1A; SMURF1; NDR1; ACVR2A; BMP5; CHD; EP300; NOG
    Hippo signaling pathway WWTR1; DLG3; AREG; APC2; CCND1; MOB1A; NF2; GSK3B; BIRC2; SOX2
    Signaling pathways regulating pluripotency of stem cells WNT5A; LHX5; ZIC3; GSK3B; ID4; REST; POU5F1; ACVR1C; GRB2; FZD1
    Transcriptional misregulation in cancer TLX1; MLLT3; HOXA10; GOLPH3L; FLT3; BMI1; BCL2A1A; HIST2H3C1; DEFA3; H3F3B

    SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SIX5; ESR1; OVOL1; FUBP3; RBPJL; ZNF664; PITX1; TXK; EGR2; NKX2
    RNA polymerase II core promoter sequence-specific DNA binding SUZ12; TBR1; SOX11; SPI1; GATA3; H2AFZ; GATA1; TP53; HEYL; H3F3B
    co-SMAD binding USP9X; TGIF1; TRIM33; SMAD1; SMAD6; SMAD2; SMAD3; FOXH1; CITED1; GATA4
    identical protein binding VIM; SMAD6; SERPINA1; CDC42; USP15; SYNE1; PPP1R13L; HAPLN2; C1QTNF6; PAICS
    metal ion binding ZRSR2; ANG3; CRYAB; ZFP36L1B; ZFP710; ZNF615; ZNF83; BIRC5; ADNP2; EGR2A
    protein binding RASL10B; KRT40; MCM6; PTPN11; PDE4C; ZFC3H1; TMIGD2; C2orf28; NARG2; DUSP2
    protein heterodimerization activity MYOG; APOA2; FLOT1; TRP53; TIRAP; ENO3; KCNB1; TAF6L; HIST2H3C; H3F3B.1
    protein homodimerization activity CDA; HNF1B; RELA; CADM2; RAB11FIP4; CHMP4B; UGT1A6; ABCD3; HMGCR; CADM4
    protein kinase binding TEX14; TELO2; SLC12A4; CD226; MAPK4; KIF13B; CCNK; GCSAM; IL31RA; ELP2
    receptor signaling protein activity DCLK1; BAG4; cgr2b; CD19; KLK1B4; PLCE1; ADCYAP1; TGFBR1; DOK1; TIAM2
    transcription factor activity, sequence-specific DNA binding FOXA3; POU1F1; NEUROG1; RUNX1; DMRT3; HOXC6A; ELK3; PLAGL2; FOXJ1A; PBX1B
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NKX2-5; GABPA; NFYC; CDX4; PAX5; SIX2; TCF12; MYC; NFATC2; GATA1
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD3; SMAD1; SMAD2; SMAD9

    SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.

    SMAD4; GSK3B; AR

    Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
    Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).


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