SMAD1 Protein


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Official Full Name SMAD family member 1
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Synonyms SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mamanlian cells
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD1-1092H Recombinant Human SMAD Family Member 1, GST-tagged E.coli GST
    Human SMAD1-11H Recombinant Human SMAD1, His-tagged E.coli His
    Human SMAD1-12H Recombinant Human SMAD1, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD1-160H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-161H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-2799H Recombinant Human SMAD1, GST-tagged E.coli GST
    Human SMAD1-30445TH Recombinant Human SMAD1 E.coli N/A
    Human SMAD1-43H Recombinant Human SMAD1 protein, GST-tagged E.coli GST
    Mouse SMAD1-15584M Recombinant Mouse SMAD1 Protein Mammalian Cell His
    Mouse Smad1-657M Recombinant Mouse Smad1 protein, His & T7-tagged E.coli His/T7
    Rat Smad1-658R Recombinant Rat Smad1 protein, His-tagged E.coli His
    Rhesus Macaque SMAD1-4329R Recombinant Rhesus monkey SMAD1 Protein, His-tagged Mammalian Cell His
    Chicken SMAD1-4493C Recombinant Chicken SMAD1 Mammalian Cell His
    Zebrafish SMAD1-8936Z Recombinant Zebrafish SMAD1 Mammalian Cell His
    Cattle SMAD1-656C Recombinant Cattle SMAD1 protein, His & T7-tagged E.coli His/T7
    Human SMAD1-1677HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
    Human SMAD1-1678HCL Recombinant Human SMAD1 293 Cell Lysate HEK293 N/A
    Human SMAD1-4856HFL Recombinant Full Length Human SMAD1, Flag-tagged Mamanlian cells Flag
    Human SMAD1-6690HF Recombinant Full Length Human SMAD1 Protein, GST-tagged E.coli GST
    Human SMAD1-1916H Recombinant Human SMAD1 Protein, His-tagged E.coli His
    Human SMAD1-333H Recombinant Human SMAD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Smad1-5949M Recombinant Mouse Smad1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway BAMBIA; BMP8B; MAPK3; SMAD5; ACVR2AA; NOG; GDF7; RHOAA; CHRD; CHD
    Hippo signaling pathway FZD2; GDF6; WNT8B; BMPR1B; LATS1; APC2; WNT3; PPP2R1A; JUB; GDF7
    Signaling pathways regulating pluripotency of stem cells WNT9A; INHBC; AKT2; PIK3R3; MYF5; ESX1; SMARCAD1; WNT3; FGFR1; FZD2
    Transcriptional misregulation in cancer CCNA1; GOLPH3L; CCNT2; PBX3; CD86; RUNX2; TGFBR2; RXRG; FUT8; DOT1L

    SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CRX; EHF; LEF1; NR4A3; MED1; KCNIP3; ZNF257; FOSL2; CREB1; EBF2
    RNA polymerase II core promoter sequence-specific DNA binding SFPI1; HNF4A; WBP2; ZFPM1; GBX2; GATA1; SMAD1; EGR1; ZNF277; NLRC5
    co-SMAD binding GATA4; SMAD6; SMAD2; TRIM33; SMAD3; USP9X; FOXH1; SMAD1; TGIF1; CITED1
    identical protein binding PHC2; EID3; SSNA1; LYZ2; EPOR; CLDN15; CLDN14; KHDRBS1; PAK2; CXADR
    metal ion binding KITA; DNAJA3B; ZNF800; CA4A; ZNF16; ZBTB7C; ZFP629; PRLR; ATX1; NIM1
    protein binding ERN1; CTCF; FRMD7; SNRPG; TXNRD2; RCOR2; RPL11; PFKL; EIF4A3; KRT79
    protein heterodimerization activity SIM1; HIST1H3D; KCNN1; SMC4; SOX9; SMC3; DMRT3; RALGAPA1; SEPHS1; ENO2
    protein homodimerization activity SHMT1; PDCD10; MBL1; TYW5; TESC; TDG; DGCR8; ERBB3; PEX7; DMRT1
    protein kinase binding STK39; BAD; BCL10; PTPN2; CHEK2; FGF19; CDKN2D; GCET2; NSF; TOM1L1
    receptor signaling protein activity IL1RL1; TIAM2; RAF1A; RGS12B; TGFBR1; BAG1; FLRT1; FLRT2; TYROBP; Siglece
    transcription factor activity, sequence-specific DNA binding SHOX; ZNF773; FOXH1; PA2G4; FOXQ1B; MYCS; DMRT1; NR2F2; ASCL1; GATA2B
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HEYL; EBF4; MYBL2; FOS; PPARA; HOXA7; GLI3; GCM1; SMAD1; NFIA
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD9; SMAD3; SMAD1; SMAD2

    SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.

    SMAD4; GSK3B; AR

    Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
    Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).


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