Recombinant Rat Smad1 protein, His-tagged
Cat.No. : | Smad1-658R |
Product Overview : | Recombinant Rat Smad1 aa. (His273~Ser468 (Accession # P97588)) fused with N-terminal His tag was produced in E. coli cells. |
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Description : | A transcriptional activator; activated by bone morphogenetic protein 4 (BMP4). |
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 25kDa as determined by SDS-PAGE reducing conditions |
Protein length : | His273~Ser468 (Accession # P97588) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 7. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Smad1 SMAD family member 1 [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Smad1 |
Synonyms : | Smad1; SMAD family member 1; Madh1; mothers against decapentaplegic homolog 1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog1 (mothers against decapentaplegic, Drosophila); SMAD 1; SMAD, mothers against DPP homolog 1; mothers against DPP homolog 1 |
Gene ID : | 25671 |
mRNA Refseq : | NM_013130.2 |
Protein Refseq : | NP_037262.2 |
UniProt ID : | P97588 |
Products Types
◆ Recombinant Protein | ||
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SMAD1-8456M | Recombinant Mouse SMAD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMAD1-333H | Recombinant Human SMAD1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
SMAD1-4145R | Recombinant Rhesus Macaque SMAD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SMAD1-1678HCL | Recombinant Human SMAD1 293 Cell Lysate | +Inquiry |
SMAD1-1677HCL | Recombinant Human SMAD1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.
This versatility allows me to explore different aspects of my research with confidence and accuracy.
The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.
Q&As (5)
Ask a questionTechniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.
Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.
Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.
SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.
Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.
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