Recombinant Human SMAD1, GST-tagged
Cat.No. : | SMAD1-2799H |
Product Overview : | Recombinant Human SMAD1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | October 23, 2024 |
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Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 19-229aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | SMAD1 SMAD family member 1 [ Homo sapiens ] |
Official Symbol : | SMAD1 |
Synonyms : | SMAD1; SMAD family member 1; MAD, mothers against decapentaplegic homolog 1 (Drosophila) , MADH1, SMAD, mothers against DPP homolog 1 (Drosophila); mothers against decapentaplegic homolog 1; JV4 1; MADR1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1; BSP1; JV41; BSP-1; JV4-1; MADH1; |
Gene ID : | 4086 |
mRNA Refseq : | NM_001003688 |
Protein Refseq : | NP_001003688 |
MIM : | 601595 |
UniProt ID : | Q15797 |
Chromosome Location : | 4q31.21 |
Pathway : | ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; ErbB1 downstream signaling, organism-s |
Function : | I-SMAD binding; RNA polymerase II core promoter sequence-specific DNA binding; co-SMAD binding; identical protein binding; protein binding; protein kinase binding; receptor signaling protein activity; sequence-specific DNA binding transcription factor act |
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◆ Lysates | ||
SMAD1-1678HCL | Recombinant Human SMAD1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.
This versatility allows me to explore different aspects of my research with confidence and accuracy.
The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.
Q&As (5)
Ask a questionTechniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.
Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.
Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.
SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.
Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.
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