Active Recombinant Full Length Human SMAD1 Protein, GST-tagged
Cat.No. : | SMAD1-6690HF |
Product Overview : | Full-length human Smad1 [1-465(end) amino acids of accession number NP_005891.1] was expressed as N-terminal GST-fusion protein (79 kDa) using E.coli expression system. GST-Smad1 was purified by using glutathione sepharose chromatography. |
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Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Bio-activity : | The phosphorylational ability of the protein was determined by ELISA. The substrate protein was incubated with the indicated enzyme, and after stopping kinase reaction by EDTA, the reaction solution was transferred into glutathione-coated plate. Phosphorylation was detected by anti-phospho antibody and HRP-labeled anti-rabbit IgG |
Protein length : | 1-465(end) |
Purity : | 78% |
Applications : | SDS-PAGE |
Storage : | Store at -80C. Avoid repeating freeze-thaws. |
Gene Name : | SMAD family member 1 |
Official Symbol : | SMAD1 |
Synonyms : | MADH1; MADR1; JV4-1 |
Protein Refseq : | NP_005891.1 |
UniProt ID : | Q15797 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.
This versatility allows me to explore different aspects of my research with confidence and accuracy.
The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.
Q&As (5)
Ask a questionTechniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.
Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.
Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.
SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.
Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.
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