Recombinant Full Length Human SMAD1 Protein, N-His-tagged
Cat.No. : | SMAD1-106HFL |
Product Overview : | Recombinant Full Length Human SMAD1 Protein, fused to His-tag at N-terminus, was expressed in E. coli. |
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Description : | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl. |
Molecular Mass : | 52.1 kDa |
AA Sequence : | A DNA sequence encoding human full-length SMAD1. |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Protein Families : | Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors |
Protein Pathways : | TGF-beta signaling pathway |
Gene Name : | SMAD1 SMAD family member 1 [ Homo sapiens (human) ] |
Official Symbol : | SMAD1 |
Synonyms : | BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1 |
Gene ID : | 4086 |
mRNA Refseq : | NM_005900.3 |
Protein Refseq : | NP_005891.1 |
MIM : | 601595 |
UniProt ID : | Q15797 |
Products Types
◆ Recombinant Protein | ||
SMAD1-8456M | Recombinant Mouse SMAD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMAD1-4145R | Recombinant Rhesus Macaque SMAD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SMAD1-333H | Recombinant Human SMAD1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Smad1-5949M | Recombinant Mouse Smad1 Protein, Myc/DDK-tagged | +Inquiry |
SMAD1-1916H | Recombinant Human SMAD1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SMAD1-1678HCL | Recombinant Human SMAD1 293 Cell Lysate | +Inquiry |
SMAD1-1677HCL | Recombinant Human SMAD1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWhether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.
This versatility allows me to explore different aspects of my research with confidence and accuracy.
The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.
Q&As (5)
Ask a questionTechniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.
Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.
Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.
SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.
Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.
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