SMAD9
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Official Full Name
SMAD family member 9 -
Overview
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SMAD9;SMAD family member 9;MAD, mothers against decapentaplegic homolog 9 (Drosophila) , MADH6, MADH9, SMAD, mothers against DPP homolog 9 (Drosophila);mothers against decapentaplegic homolog 9;MAD homolog 9;MADH6;Mothers against decapentaplegic;SMAD 9;SMAD, mothers against DPP homolog 9 (Drosophila);SMAD8A;SMAD8B;SMAD, mothers against DPP homolog 9;Mothers against decapentaplegic, drosophila, homolog of, 9;MADH9;SMAD8
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SMAD9 involved in several pathways and played different roles in them. We selected most pathways SMAD9 participated on our site, such as TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | PIK3CA,INHBA,SMAD2,LIF,SMAD5,WNT7A,WNT2B,SMAD1,NRAS,FZD7 |
| TGF-beta signaling pathway | INHBC,MYCB,TFDP1,BMP7,RHOAA,CUL1B,THBS1,CUL1,RPS6KB2,E2F5 |
Protein Function
SMAD9 has several biochemical functions, for example, DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD9 itself. We selected most functions SMAD9 had, and list some proteins which have the same functions with SMAD9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | HNF4G,ZFP518A,FOXA3,ZNF789,ATF2,SP1,ARNTL1A,TARDBP,ZNF75D,PPARG |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | SMAD2,SMAD1,SMAD3 |
| metal ion binding | HDAC7,NPEPPS,MT2,ADI1,HSPG2,HDAC7A,ZNF71,PPP4CB,GALNS,ZMYND10 |
| protein binding | CENPK,ASAP2,APOD,METTL21C,PODXL2,DAPK3,Kitl,SLC3A2,SNRNP25,CCDC28B |
| DNA binding | CDAN1,FOXA,CREB1B,IRX5,ILF3B,POLR3B,BBX,KIF4A,FAM60AL,EHF |
Interacting Protein
SMAD9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD9.
KDM1A;PRMT6;UBA6;MTMR11;EIF3F;PIR;KMT2D;KDM6A;ZEB2;MCM3AP;MAN1A2;LRP5;SF3B1;DKK1;AP2A1;CSH1;FTL;CYP11A1
SMAD9 Related Signal Pathway
Resources
Gene Families
What Is Tumor Necrosis Factor (TNF)/TNF SuperfamilyWhat Is Tumor Necrosis Factor (TNF)/TNF Superfamily
TGF-β Superfamily Signaling
TGF-β Superfamily Signaling
Research Area
Epithelial Stem Cell Transcription FactorsMesenchymal Stem Cell Transcription Factors
Intracellular Signaling Molecules in Angiogenesis
Pluripotent Stem Cell Transcription Factors
Related Services
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References
