SMARCA5
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -
Overview
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. -
Synonyms
SMARCA5;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;hISWI;hSNF2H;ISWI;sucrose nonfermenting-like 5;sucrose nonfermenting protein 2 homolog;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5;SNF2H;WCRF135
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
SMARCA5 involved in several pathways and played different roles in them. We selected most pathways SMARCA5 participated on our site, such as Cell Cycle,Chromosome Maintenance,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | COPS5,ERCC8,PNKP,COPS3,TFPT,COPS4,DDB1,USP43A,HUS1,COPS8 |
| Deposition of new CENPA-containing nucleosomes at the centromere | CENPK,ITGB3BP,MLF1IP,CENPP,NPM1,CENPN,RBBP4,MIS18BP1,CENPH,MIS18A |
| Gene Expression | ZNF433,ZFP90,ADARB1,ZNF483,COX11,COX4I1,DARS,LAMTOR1,LAGE3,EIF4H |
| Cell cycle | ORC3,WEE2,SSNA1,GINS2,USO1,YWHAG1,POT1,MCM9,TCTN2,RBL2 |
| DNA Double-Strand Break Repair | PARP1,EYA4,RNF168,EME2,DNA2,KDM4A,UBE2V2,PAXIP1,TDP2,BARD1 |
| Chromosome Maintenance | DNA2,NPM1,APITD1,HJURP,POT1A,CENPL,DKC1,POLD3,RBBP4,RUVBL2 |
| Epigenetic regulation of gene expression | RRP8,H3F3D,UHRF1,SAP18,SAP130,EFCAB11,SUZ12A,DNMT1,TAF1C,PHF19 |
| DNA Double Strand Break Response | BAZ1B,EYA2,EYA4,UBE2V2,BARD1,FAM175A,EYA3,THRSP,CHEK2,BRCC3 |
Protein Function
SMARCA5 has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA5 itself. We selected most functions SMARCA5 had, and list some proteins which have the same functions with SMARCA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| helicase activity | DHX34,DHX32A,ZRANB3,DNA2,SMARCAL1,TDRD12,BAT1,DDX19,HELZ,HELLS |
| DNA binding | POU2AF1,HIST1H2BM,POLR1D,POLR2E,TNP1,YEATS4,TMPO,TCF25,ZNF155,ZBTB42 |
| nucleosome binding | RNF168,RNF169,ZNHIT1,RNF4,HP1BP3,L3MBTL1,DNTTIP1,ARID1A,NOC2L,MUM1 |
| protein binding | IRF5,TXLNB,ZNF747,TET3,KPNA3,NPRL2,WDYHV1,BRE,NDC80,IL17RA |
| ATP binding | SPS2,RIPK3,DHX58,SMARCA4A,UBE2T,STK26,STK30,PFKFB2A,MAPKAPK5,MOCS3 |
| ATPase activity | OLA1,ABCE1,VPS4B,PMS2,KIF27,KIF2C,MYH8,ABCG2D,KIFC3,ABCC1 |
Interacting Protein
SMARCA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA5.
BAZ1B;RSF1;HIST2H4B;MYC;ESR2;DBP
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