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Official Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Background The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2; Rsc8; BAF170; CRACC2; SWI/SNF complex subunit SMARCC2; SWI3-like protein; BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; chromatin remodeling complex BAF170 subunit; mammalian chromatin remodeling complex BRG1-associated factor 170; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2;
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Smarcc2-5962M Recombinant Mouse Smarcc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SMARCC2-1669HCL Recombinant Human SMARCC2 293 Cell Lysate HEK293 N/A
    Human SMARCC2-2416H Recombinant Human SMARCC2, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMARCC2-31424TH Recombinant Human SMARCC2 Wheat Germ N/A

    smarcc2 involved in several pathways and played different roles in them. We selected most pathways smarcc2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with smarcc2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes GATAD2A; CHD4A; MORF4L1; SMARCE1; ELP4; EED; VPS72; ARID1A; PRMT7; EPC1
    Chromatin organization PHF17; KDM5B; KIAA1267; KDM6AL; MORF4L1; SUZ12A; ELP3; DPY30; EPC1; GATAD2AB
    Glucocorticoid receptor regulatory network SMARCC2; CSN2; SMARCA4; BGLAP; KRT14; NR1I3; KRT5; POU2F1; EGR1; SMARCD1
    Prostate Cancer CCNE1; BAD; Ar; PIK3R5; ARAF; MAPK1; NDRG1; CCND1; EP300; FOXA1
    RMTs methylate histone arginines ARID2; SMARCA4; PRMT5; PBRM1; SMARCD1; SMARCC2; SMARCC1; SMARCA2; ACTL6B; SMARCC1B
    TNF-alpha/NF-kB Signaling Pathway COPS3; FAF1; TNIP1; ZFAND5; CRADD; USP2; NKIRAS1; PEG3; TRAIP; SMARCE1

    smarcc2 has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding, contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding, contributes_to nucleosomal DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by smarcc2 itself. We selected most functions smarcc2 had, and list some proteins which have the same functions with smarcc2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding SMARCC1; MTA2; CHD4; HDAC1; SMARCA4; SMARCE1; GATAD2B; RBBP4; MBD3; HDAC2
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding CHD4; GATAD2B; SMARCE1; RBBP4; SMARCC1; HDAC1; MBD3; SMARCB1; SMARCC2; HDAC2
    contributes_to nucleosomal DNA binding HDAC1; SMARCC1; MBD3; SMARCB1; SMARCC2; GATAD2B; ACTB; HDAC2; MTA2; ACTL6A
    protein binding CNOT6L; PEX10; MBD4; CCDC103; KAZN; FTL; PPP1R2P3; GNPDA2; GAST; U2AF2
    transcription coactivator activity NR2C2; HIF3A; NCOA1; KAT5; COPS5; TFDP1A; RNF14; MED17; RUNX1; NFYC

    smarcc2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with smarcc2 here. Most of them are supplied by our site. Hope this information will be useful for your research of smarcc2.


    Wang, XM; Liao, DW; et al. Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes. HYBRIDOMA 24:55-57(2005).

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