SMG6
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Official Full Name
SMG6 nonsense mediated mRNA decay factor -
Overview
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014] -
Synonyms
SMG6;SMG6 nonsense mediated mRNA decay factor;EST1A;SMG-6;C17orf31;hSMG5/7a;telomerase-binding protein EST1A;telomerase subunit EST1A;ever shorter telomeres 1A;EST1 telomerase component homolog A;smg-6 homolog, nonsense mediated mRNA decay factor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMG6-15624M | Recombinant Mouse SMG6 Protein | Mammalian Cells | Mouse | His |
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| SMG6-8479M | Recombinant Mouse SMG6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| SMG6-8479M-B | Recombinant Mouse SMG6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SMG6 involved in several pathways and played different roles in them. We selected most pathways SMG6 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMG6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | EIF4A3,PAPOLB,ETF1A,NCBP1,PPP1CAB,PPP2R5EA,PPP1CBL,PPP2R5B,UPF3B,GSPT1 |
Protein Function
SMG6 has several biochemical functions, for example, DNA binding,T/G mismatch-specific endonuclease activity,endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMG6 itself. We selected most functions SMG6 had, and list some proteins which have the same functions with SMG6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| T/G mismatch-specific endonuclease activity | RNASEKA,REXO4,TMPPE,MEIOB,REXO1,RNASEKB,GDPD4,ENDOU2,ZRANB3,RAG1 |
| metal ion binding | ZNF444,KDM8,DGKZ,ATF7A,ZFP42,EGR2A,PCGF5B,ZNF134,BTK,ZFP131 |
| phosphoric ester hydrolase activity | FBP1A,REXO4,SACM1LA,MEIOB,RAG1,ZRANB3,ENDOU2,TMPPE,EXO5,REXO1 |
| endonuclease activity | ZC3H12A,EAR14,MRE11A,RNASE3,RNASE6,EAR2,RNASEL3,EXOG,EAR3,OGG1 |
| hydrolase activity | FAAH2A,KLK1B24,DDHD2,GLA,EAR2,FBP1A,ADPRM,HE1A,RPE65B,GZME |
| endoribonuclease activity | PLD6,TSNAX,NOB1,DICER1,RNASEKA,ENDOU,ENDOU2,AGO2,TSN,RNASEL |
| DNA binding | HIST1H2AC,HMX3,PAX4,FOXI3A,HIC2,CHD8,YBX2,ORC1L,HMGN1,NFE2L2 |
| retroviral 3 processing activity | RAG1,REXO1,RNASEKA,ENDOU2,REXO4,EXO5,RNASEKB,TMPPE,GDPD4,ZRANB3 |
| nuclease activity | RNASEL2,DNA2,DNASE1L3L,TDP2,EAR2,ENDOG,RNASEKB,DOM3Z,EAR5,RNASEL3 |
Interacting Protein
SMG6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMG6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMG6.
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References
- Schmidt, SA; Foley, PL; et al. Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. NUCLEIC ACIDS RESEARCH 43:309-323(2015).
- Wilusz, JE; Wilusz, J; et al. Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production. GENES & DEVELOPMENT 28:2447-2449(2014).
