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SNX13

Official Full Name

sorting nexin 13
Overview

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.
Synonyms

SNX13; sorting nexin 13; sorting nexin-13; KIAA0713; RGS PX1; RGS domain and PHOX domain containing protein; rgs domain- and phox domain-containing protein; RGS-PX1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SNX13-1600HCL	Recombinant Human SNX13 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SNX13-394H	Recombinant Human SNX13 Protein, His-tagged	E.coli	His	Ala97~Asn284	Inquiry
Chicken	SNX13-3758C	Recombinant Chicken SNX13	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SNX13 Related Articles

SNX13 involved in several pathways and played different roles in them. We selected most pathways SNX13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SNX13 has several biochemical functions, for example, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX13 itself. We selected most functions SNX13 had, and list some proteins which have the same functions with SNX13. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol binding	PIK3C2A;PIK3C2G;SNX6;SGK3;NOXO1;SNX25;RAG2;FCHO2;SNX32
phosphatidylinositol-3-phosphate binding	SNX13;LANCL2;PHLDA3;NCF4;SNX21;SNX24;ZFYVE26;WDR45L;FAM21C

SNX13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX13.

TDP2; G6PC; NR1I3; KLF15; pi3p

Li, J; Li, CM; et al. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. NATURE COMMUNICATIONS 5:-(2014).

Angel, JM; Abel, EL; et al. Fine Mapping Reveals That Promotion Susceptibility Locus 1 (Psl1) Is a Compound Locus With Multiple Genes That Modify Susceptibility to Skin Tumor Development. G3-GENES GENOMES GENETICS 4:1071-1079(2014).