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SNX14

Official Full Name

sorting nexin 14
Overview

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms

SNX14; sorting nexin 14; sorting nexin-14; RGS PX2; MGC13217; RGS-PX2; RP11-321N4.2; SNX14_HUMAN; OTTHUMP00000016812; OTTHUMP00000016813; OTTHUMP00000220929; OTTHUMP00000220930; OTTHUMP00000220931; OTTHUMP00000220932;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SNX14-2856H	Recombinant Human SNX14, GST-tagged	E.coli	GST	596-893aa	$319 / 25μg
Human	SNX14-1659HCL	Recombinant Human SNX14 cell lysate		Non		Inquiry
Rhesus Macaque	SNX14-4390R	Recombinant Rhesus monkey SNX14 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SNX14-4206R	Recombinant Rhesus Macaque SNX14 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	SNX14-4206R-B	Recombinant Rhesus Macaque SNX14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SNX14-3933Z	Recombinant Zebrafish SNX14	Mammalian Cell	His		Inquiry
Chicken	SNX14-3350C	Recombinant Chicken SNX14	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SNX14 involved in several pathways and played different roles in them. We selected most pathways SNX14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SNX14 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX14 itself. We selected most functions SNX14 had, and list some proteins which have the same functions with SNX14. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol-3,5-bisphosphate binding	JPH2;WIPI2;SNX14;FAM21C;CLVS2;WIPI1;CLVS1;WDR45L;WDR45B

SNX14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX14 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX14.

q99ib8-pro_0000045601; pi3p

Research Area

Thomas, AC; Williams, H; et al. Mutations in SNX14 Cause a Distinctive Autosomal-Recessive Cerebellar Ataxia and Intellectual Disability Syndrome. AMERICAN JOURNAL OF HUMAN GENETICS 95:611-621(2014).

Huang, HS; Yoon, BJ; et al. Snx14 Regulates Neuronal Excitability, Promotes Synaptic Transmission, and Is Imprinted in the Brain of Mice. PLOS ONE 9:-(2014).