SNX15

  • Official Full Name

    sorting nexin 15

  • Overview

    This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.

  • Synonyms

    SNX15;sorting nexin 15;sorting nexin-15;Clone iota unknown protein;SNX 15;OTTHUMP00000035515;OTTHUMP00000230789;OTTHUMP00000230840;OTTHUMP00000230841;HSAF001435

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc

    Involved Pathway

    SNX15 involved in several pathways and played different roles in them. We selected most pathways SNX15 participated on our site, such as PDGFR-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PDGFR-beta signaling pathway SLC9A3R1,DOK1,SLA,GRB10

    Protein Function

    SNX15 has several biochemical functions, for example, phosphatidylinositol binding,protein binding,NOT protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX15 itself. We selected most functions SNX15 had, and list some proteins which have the same functions with SNX15. You can find most of the proteins on our site.

    Function Related Protein
    NOT protein serine/threonine kinase activity FAM20A,STRADB,STRADA
    protein binding SEPT1,DDRGK1,TXK,ECT2,DAAM1,KIF22,PPIE,FOSL2,LSM5,C6
    phosphatidylinositol binding SNX2,PIK3C2A,SNX17,MITD1,FES,MTM1,SNX22,RPS6KC1,SNX25,PXK

    Interacting Protein

    SNX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX15.

    REEP6;RTN4;RABAC1;ARL6IP1;KDM1A;SARAF;pi3p

    Resources

    References

    • Iwaya, N; Takasu, H; et al. MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain. JOURNAL OF BIOCHEMISTRY 153:473-481(2013).
    • Landi, A; Vermeire, J; et al. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. RETROVIROLOGY 11:-(2014).

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