SNX15

  • Official Full Name

    sorting nexin 15

  • Overview

    This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
  • Synonyms

    SNX15; sorting nexin 15; sorting nexin-15; Clone iota unknown protein; SNX 15; OTTHUMP00000035515; OTTHUMP00000230789; OTTHUMP00000230840; OTTHUMP00000230841; HSAF001435;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNX15-2857H Recombinant Human SNX15, His-tagged E.coli His 1-342aa
Human SNX15-1660HCL Recombinant Human SNX15 cell lysate N/A
Human SNX15-2244H Recombinant Human SNX15 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SNX15-2417H Recombinant Human SNX15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SNX15-2064H Recombinant Human SNX15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SNX15-2064H-B Recombinant Human SNX15 Protein Pre-coupled Magnetic Beads HEK293
Human SNX15-2090HFL Recombinant Full Length Human SNX15 Protein, C-Flag-tagged Mammalian cells Flag
Mouse SNX15-15717M Recombinant Mouse SNX15 Protein Mammalian Cell His
Mouse SNX15-8547M-B Recombinant Mouse SNX15 Protein Pre-coupled Magnetic Beads HEK293
Mouse SNX15-8547M Recombinant Mouse SNX15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Snx15-6023M Recombinant Mouse Snx15 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SNX15-5653R Recombinant Rat SNX15 Protein Mammalian Cell His
Rat SNX15-5312R Recombinant Rat SNX15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SNX15-5312R-B Recombinant Rat SNX15 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SNX15-6270Z Recombinant Zebrafish SNX15 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SNX15 involved in several pathways and played different roles in them. We selected most pathways SNX15 participated on our site, such as PDGFR-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PDGFR-beta signaling pathwaySLA;DOK1;SLC9A3R1;GRB10;SNX15

SNX15 has several biochemical functions, for example, phosphatidylinositol binding, protein binding, NOT protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX15 itself. We selected most functions SNX15 had, and list some proteins which have the same functions with SNX15. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol bindingSNX2;SNX7;PLD1;SGK3;SH3YL1;SNX29;SNX1;PXK;MTM1
protein bindingZBED4;NCS1;PIH1D3;ASF1A;PPP2CB;EFCAB12;CFL2;PPP6C;TA
NOT protein serine/threonine kinase activitySTRADA;FAM20A;STRADB;SNX15

SNX15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX15 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX15.

REEP6; RTN4; RABAC1; ARL6IP1; KDM1A; SARAF; pi3p

Research Area

Related articles

Landi, A; Vermeire, J; et al. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. RETROVIROLOGY 11:-(2014).
Iwaya, N; Takasu, H; et al. MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain. JOURNAL OF BIOCHEMISTRY 153:473-481(2013).
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