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SNX4

  • Official Full Name

    sorting nexin 4

  • Overview

    This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.
  • Synonyms

    SNX4; sorting nexin 4; sorting nexin-4; ATG24B; SNX 4; SNX4_HUMAN; OTTHUMP00000215866;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNX4-2864H Recombinant Human SNX4, GST-tagged E.coli GST C-term-300aa
Human SNX4-31429TH Recombinant Human SNX4, His-tagged E.coli His
Human SNX4-1663HCL Recombinant Human SNX4 cell lysate N/A
Human SNX4-2323H Recombinant Human SNX4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse SNX4-15735M Recombinant Mouse SNX4 Protein Mammalian Cell His
Mouse SNX4-8559M Recombinant Mouse SNX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Snx4-6035M Recombinant Mouse Snx4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SNX4-8559M-B Recombinant Mouse SNX4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SNX4-2267Z Recombinant Zebrafish SNX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SNX4 involved in several pathways and played different roles in them. We selected most pathways SNX4 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisRAB11FIP1;SNX6;PRKCI;PIP5K1C;ARR3A;VPS4A;SNX1;BC2;DDL-2

SNX4 has several biochemical functions, for example, epidermal growth factor receptor binding, insulin receptor binding, leptin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX4 itself. We selected most functions SNX4 had, and list some proteins which have the same functions with SNX4. You can find most of the proteins on our site.

Function Related Protein
epidermal growth factor receptor bindingTNK2;SNX1;EREG;FAM83B;LINGO1B;YES1;TGFA;HBEGFA;VAV3
insulin receptor bindingPIK3R1;IGF1R;PTPN1;DOK7;IRS4;LMBRD1;IGF2;INSL3;DOK2
leptin receptor bindingSNX2;SNX1;SNX4
phosphatidylinositol bindingSLC12A9;PIK3C2A;MTM1;SNX27A;SNX10B;SH3PXD2A;SNX9;HIP1;TULP3
protein bindingTEN1;SF3B2;ZNRF1;MLANA;PDE3B;DAZL;PTPN11;PRELID1;EBF1
transferrin receptor bindingHFE2;SNX2;Trf;TF;SNX1;RGMA;SNX4;CD81;HFE

SNX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX4.

MAGEA6; ARL6IP1; BIN1; Bin1; SNX30; SNX7; SUPT5H; brrf1_ebvg; HIVEP1

Research Area

Related articles

Ghai, R; Tello-Lafoz, M; et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. JOURNAL OF CELL SCIENCE 128:553-565(2015).
Tseng, HY; Thorausch, N; et al. Sorting Nexin 31 Binds Multiple beta Integrin Cytoplasmic Domains and Regulates beta 1 Integrin Surface Levels and Stability. JOURNAL OF MOLECULAR BIOLOGY 426:3180-3194(2014).
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