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SNX4

Official Full Name

sorting nexin 4
Overview

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.
Synonyms

SNX4; sorting nexin 4; sorting nexin-4; ATG24B; SNX 4; SNX4_HUMAN; OTTHUMP00000215866;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SNX4-2864H	Recombinant Human SNX4, GST-tagged	E.coli	GST	C-term-300aa	$319 / 25μg
Human	SNX4-31429TH	Recombinant Human SNX4, His-tagged	E.coli	His	1-450	Inquiry
Human	SNX4-1663HCL	Recombinant Human SNX4 cell lysate		Non		Inquiry
Human	SNX4-2323H	Recombinant Human SNX4 Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Mouse	SNX4-15735M	Recombinant Mouse SNX4 Protein	Mammalian Cell	His		Inquiry
Mouse	SNX4-8559M	Recombinant Mouse SNX4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	Snx4-6035M	Recombinant Mouse Snx4 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	SNX4-8559M-B	Recombinant Mouse SNX4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SNX4-2267Z	Recombinant Zebrafish SNX4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SNX4 involved in several pathways and played different roles in them. We selected most pathways SNX4 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	CHMP5B;MVB12BB;HLA-A;KIF5A;TGFBR2;ARPC4L;KIF5B;IL2RG;PRKCI

SNX4 has several biochemical functions, for example, epidermal growth factor receptor binding, insulin receptor binding, leptin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX4 itself. We selected most functions SNX4 had, and list some proteins which have the same functions with SNX4. You can find most of the proteins on our site.

Function	Related Protein
epidermal growth factor receptor binding	ATXN2;FAM83B;SNX1;MS4A1;LINGO1;TGFA;SNX4;EPGN;EFEMP1
insulin receptor binding	PDPK1;INSL3;DOK2;PHIP;GRB10;DOK1B;IGF2;SLC2A2;IRS1
leptin receptor binding	SNX4;SNX1;SNX2
phosphatidylinositol binding	SNX6;GRB7;SNX1;MTM1;TULP3;SNX22;ZCCHC2;FCHO2;SH3YL1
protein binding	MAGEH1;CAMK2G;SP2;SPATA24;CRHBP;CHD1;EYA4;CENPJ;WNT11
transferrin receptor binding	HFE;TF;CD81;HFE2;SNX1;SNX4;SNX2;Trf;RGMA

SNX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX4.

MAGEA6; ARL6IP1; BIN1; Bin1; SNX30; SNX7; SUPT5H; brrf1_ebvg; HIVEP1

Research Area

Ghai, R; Tello-Lafoz, M; et al. Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. JOURNAL OF CELL SCIENCE 128:553-565(2015).

Tseng, HY; Thorausch, N; et al. Sorting Nexin 31 Binds Multiple beta Integrin Cytoplasmic Domains and Regulates beta 1 Integrin Surface Levels and Stability. JOURNAL OF MOLECULAR BIOLOGY 426:3180-3194(2014).