SOCS4

  • Official Full Name

    suppressor of cytokine signaling 4

  • Overview

    The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    SOCS4; suppressor of cytokine signaling 4; SOCS7, suppressor of cytokine signaling 7; SOCS-4; SOCS-7; suppressor of cytokine signaling 7; SH2 domain containing SOCS box protein; SOCS7; DKFZp686J1568;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOCS4-344H Recombinant Human SOCS4 Protein, His-tagged E.coli His
Human SOCS4-345H Recombinant Human SOCS4 Protein, His-tagged E.coli His
Human SOCS4-1666HCL Recombinant Human SOCS4 cell lysate N/A
Rhesus Macaque SOCS4-4403R Recombinant Rhesus monkey SOCS4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOCS4-4219R Recombinant Rhesus Macaque SOCS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOCS4-4219R-B Recombinant Rhesus Macaque SOCS4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SOCS4-6262Z Recombinant Zebrafish SOCS4 Mammalian Cell His
Chicken SOCS4-4238C Recombinant Chicken SOCS4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SOCS4 Related Signal Pathway

SOCS4 involved in several pathways and played different roles in them. We selected most pathways SOCS4 participated on our site, such as Insulin signaling pathway, Jak-STAT signaling pathway, Kit Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Insulin signaling pathwayPTPN1;PHKG1B;PHKB;PRKAR2A;PHKG2;PDPK1;PRKAR1AB;ACACA;PRKAG2
Jak-STAT signaling pathwayLEPR;IL2RG;IFNA12;IL6;CCND3;TSLP;SOCS5B;IFNG;IL2RGA
Kit Receptor Signaling PathwaySPRED2B;PTPRUB;DOK1B;GRAPA;GRAP;STAP1;PTPRU;SOCS4;GRB7
Prolactin signaling pathwaySOCS5;PRP2;MAP2K1;TNFRSF11A;SOCS4;AKT2;MAPK3;ELF5;ESR1
Type II diabetes mellitusPIK3CA;PIK3CD;PIK3R1;MAPK9;INS2;PRKCD;PRKCE;TNF;PIK3R5

SOCS4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS4 itself. We selected most functions SOCS4 had, and list some proteins which have the same functions with SOCS4. You can find most of the proteins on our site.

Function Related Protein
protein bindingPRICKLE1;C18orf1;SLA2;LRRC75A-AS1;BRMS1;RRAD;DPF2;MAGED1;PAQR5

SOCS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS4.

GRB2; PIK3R3; RBP7; PINK1; FRS3; ppapdc2; LECT1; TNK2

Research Area

Related articles

Rutz, S; Kayagaki, N; et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. NATURE 518:-(2015).
Guo, H; Wang, Y; et al. Platelet Factor 4 Limits Th17 Differentiation and Ischaemia-Reperfusion Injury After Liver Transplantation in Mice. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:129-134(2015).
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