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SOX3

Official Full Name

SRY (sex determining region Y)-box 3
Overview

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
Synonyms

SOX3; SRY (sex determining region Y)-box 3; panhypopituitarism , PHP; transcription factor SOX-3; PHP; GHDX; MRGH; PHPX; SOXB;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Rhesus Macaque	SOX3-4415R	Recombinant Rhesus monkey SOX3 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	SOX3-4231R	Recombinant Rhesus Macaque SOX3 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rhesus Macaque	SOX3-4231R-B	Recombinant Rhesus Macaque SOX3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SOX3-226Z	Recombinant Zebrafish SOX3	Mammalian Cell	His	Inquiry
Chicken	SOX3-5769C	Recombinant Chicken SOX3	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SOX3 involved in several pathways and played different roles in them. We selected most pathways SOX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SOX3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX3 itself. We selected most functions SOX3 had, and list some proteins which have the same functions with SOX3. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HIF3A;H1FX;ASCL3;RARGA;TOX3;RCOR2;TSN;KIF4A;HMGB3B
RNA polymerase II core promoter sequence-specific DNA binding	SFPI1;STAT6;H2AFY;HNF4A;MTF1;TFAP2A;SMAD5;EGR1;TAL1
RNA polymerase II transcription corepressor activity	UXT;OLIG3;SIN3AA;CTBP1;TBX15;ELANE;TXLNB;URI1;RERE
transcription factor activity, sequence-specific DNA binding	MLXIPL;RFX1A;PCGF2;ZNF287;UBN2;ZIK1;DMRTC2;ENO1;ZSCAN20

SOX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX3.

Research Area

Neural Stem Cell Transcription Factors

Pluripotent Stem Cell Transcription Factors

Rogers, N; Cheah, PS; et al. Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. GENE EXPRESSION PATTERNS 13:240-248(2013).

Hosoya, A; Kwak, S; et al. Immunohistochemical Localization of Cytokeratins in the Junctional Region of Ectoderm and Endoderm. ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY 293:1864-1872(2010).