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SP7

Official Full Name

Sp7 transcription factor
Overview

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Synonyms

SP7; Sp7 transcription factor; transcription factor Sp7; osterix; OSX; MGC126598; Sp 7; SP7_HUMAN; Zinc finger protein osterix; OTTHUMP00000242639; OTTHUMP00000242702; OI11;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SP7-5613H	Recombinant Human SP7 Protein (Ser370-Ile431), N-His tagged	E.coli	His	Ser370-Ile431	Inquiry
Human	SP7-2723H	Recombinant Human SP7 Protein, His-tagged	E.coli	His	Met19-Leu288	Inquiry
Zebrafish	SP7-12124Z	Recombinant Zebrafish SP7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SP7 involved in several pathways and played different roles in them. We selected most pathways SP7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SP7 has several biochemical functions, for example, metal ion binding, nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP7 itself. We selected most functions SP7 had, and list some proteins which have the same functions with SP7. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	COL18A1;PPARG;GALNTL1;CNOT7;FBXO30B;ATP2A1L;MPPED2;NUDT8;VEZF1
nucleic acid binding	SCRT1A;ZFP423;SRSF2B;ZBTB41;RECQL5;ZFP184;CHD6;HNRNPA0L;HIC1L

SP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP7.

Research Area

Osteoblast and Osteoclast Markers

Osteogenesis Markers

Osteoclast Markers

Osteoblast Markers

Osteoprogenitor Markers

Bozkurt, YA; Kus, S; et al. Histological and immunohistochemical studies of the structure of lymph nodes in Kilis goats. BIOTECHNIC & HISTOCHEMISTRY 89:440-445(2014).

Rashid, H; Ma, CY; et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. CONNECTIVE TISSUE RESEARCH 55:83-87(2014).