SPTB
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Official Full Name
spectrin, beta, erythrocytic -
Overview
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. -
Synonyms
SPTB;spectrin, beta, erythrocytic;spectrin beta chain, erythrocyte;spherocytosis;clinical type I;beta-I spectrin;membrane cytoskeletal protein;EL3;HS2;SPH2;HSPTB1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPTB-2659H | Recombinant Human SPTB protein, His-tagged | E.coli | Human | His | 1800-1900 aa | |
| SPTB-9074Z | Recombinant Zebrafish SPTB | Mammalian Cells | Zebrafish | His |
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| RFL3260DF | Recombinant Full Length Dictyostelium Discoideum Serine Palmitoyltransferase 2(Sptb) Protein, His-Tagged | E.coli | Dictyostelium Discoideum | His | Full L. Full Length (1-490) |
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Involved Pathway
SPTB involved in several pathways and played different roles in them. We selected most pathways SPTB participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Downstream signal transduction | WDR83,AGO1,FGF10B,FGF20A,TRAT1,FRS2B,SPTBN1,CNKSR1,SPNA1,MOV10 |
| ARMS-mediated activation | SPNA1,FRS2A,NRG3,DUSP7,PSMD9,CNKSR1,PHB,KLB,MARK3,AKAP9 |
| DAP12 interactions | SIGLEC14,SIRPB1,IL17RD,AHCYL1,JAK3,CLEC5A,PEA15,SPRED3,NRG3,AGO1 |
| Developmental Biology | NRP1A,ACTR2,EGR2,MEF2B,CFC1,FGF8B,MED26,SPTBN1,EFNA5,DUSP9 |
| DAP12 signaling | PRKAR1AA,SPTA1,GRAP2A,AGO1,SPTBN1,NEFLB,PEA15A,FGF10B,PTPRA,IL17RD |
| Axon guidance | SPNA2,SEMA3AB,SEMA3D,EPHB6,KBTBD7,EPHA3,RNF8,SCN8A,TRPC5,AP2S1 |
| Cytokine Signaling in Immune system | EIF4E3,PTPRA,FGF20A,CSF2RA,GBP4,SPRED3,TRIM46,HAVCR2,CASPBL,GBP5 |
| Downstream signaling of activated FGFR1 | MARK3,WDR83,PEA15A,PTPRA,CNKSR1,SPRED3,DUSP9,RASGRP4,PHB,SPTA1 |
Protein Function
SPTB has several biochemical functions, for example, actin binding,phospholipid binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTB itself. We selected most functions SPTB had, and list some proteins which have the same functions with SPTB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | BICD1,TUBA1A,TUBAL3,CTNNA2,ARPC3,TUBE1,CCDC6,HIP1,TUBA8L3,KRT17 |
| actin binding | PIP,WIPF2B,FHL3,EZRA,SNTG1,CAPG,CAPGA,FRG1,DIAP3,FSCN1A |
| phospholipid binding | LRBA,APOM,VAMP2,SMURF1,Defa4,PRKCI,APOB,PICALMA,SHC1,HIP1RB |
Interacting Protein
SPTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTB here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTB.
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