SPTB

  • Official Full Name

    spectrin, beta, erythrocytic
  • Overview

    This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
  • Synonyms

    SPTB;spectrin, beta, erythrocytic;spectrin beta chain, erythrocyte;spherocytosis;clinical type I;beta-I spectrin;membrane cytoskeletal protein;EL3;HS2;SPH2;HSPTB1
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPTB-2659H Recombinant Human SPTB protein, His-tagged E.coli Human His 1800-1900 aa
SPTB-9074Z Recombinant Zebrafish SPTB Mammalian Cells Zebrafish His
RFL3260DF Recombinant Full Length Dictyostelium Discoideum Serine Palmitoyltransferase 2(Sptb) Protein, His-Tagged E.coli Dictyostelium Discoideum His Full L. Full Length (1-490)

    Involved Pathway

    SPTB involved in several pathways and played different roles in them. We selected most pathways SPTB participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downstream signal transduction FGF8B,DAB2IPB,DUSP10,AGO2,CNKSR1,FRS2B,FGF20A,FRS3,RASGEF1A,FGFR1B
    Downstream signaling of activated FGFR1 SPRED3,PTPRA,PAQR3B,DUSP9,MARK3,PEA15A,WDR83,PEA15,CNKSR1,RASGEF1A
    DAP12 interactions FGFR1B,PEA15A,KBTBD7,SPRED2,NRG3,PEBP1,CLEC5A,AGO1,RASGRP1,SIGLEC15
    Cytokine Signaling in Immune system IRF4,TRIM26,PEA15,EDAR,TRIM38,EIF4A1,TRIM10,IRAK3,KPNA5,DUSP4
    ARMS-mediated activation FRS2,NRG4,FGFR1B,DUSP4,CNKSR1,SPTA1,CSF2RA,WDR83,DUSP6,PEBP1
    DAP12 signaling DUSP4,FGF8B,NRG4,PEA15A,SPTBN1,SPNA1,PAQR3B,PRKAR1AA,NEFLB,JAK3
    Axon guidance SEMA4D,MYL12B,NADL1.1,ACTR3,WDR83,NTN1B,PTPRA,CLTA,GPC1B,NCK2
    Developmental Biology NRG4,LEFTY1,KCNQ3,PAQR3A,DUSP4,DCX,SEMA3A,CLASP1,MED18,GDNF

    Protein Function

    SPTB has several biochemical functions, for example, actin binding,phospholipid binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTB itself. We selected most functions SPTB had, and list some proteins which have the same functions with SPTB. You can find most of the proteins on our site.

    Function Related Protein
    structural constituent of cytoskeleton TUBA8L2,TUBA1C,ARPC4,DSP,EPB41L3,SPTBN2,CTNNA2,SORBS3,TUBB5,ADD3
    actin binding WASLA,MTSS1LA,PALLD,ABLIM1,ACTN3A,PPP1R9B,PACRG,ABLIM1A,PFN1,PARVB
    phospholipid binding PTAFR,PACSIN1,MYOF,MTAP1B,NSFL1C,GRK5,PRKCI,ARHGAP44,RASAL1,F10

    Interacting Protein

    SPTB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTB here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTB.

    Resources

    References

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