• Official Full Name


  • Overview

    This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.
  • Synonyms

    SVIL; supervillin; archvillin; p205/p250; OTTHUMP00000019388; OTTHUMP00000019389; membrane-associated F-actin binding protein p205;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SVIL-8134H Recombinant Human SVIL protein, His-tagged E.coli His Cys1385~Leu1525 (Accession # O95425)
Human SVIL-1327HCL Recombinant Human SVIL 293 Cell Lysate HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SVIL involved in several pathways and played different roles in them. We selected most pathways SVIL participated on our site, such as Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SVIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Coregulation of Androgen receptor activityCARM1;TCF4;PIAS3;PAWR;PA2G4;PATZ1;KDM3A;CTDSP2;TMF1

SVIL has several biochemical functions, for example, actin filament binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SVIL itself. We selected most functions SVIL had, and list some proteins which have the same functions with SVIL. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingVIL1;HAND2;FSCN2;MYO1E;USH1C;AIF1L;TRPV4;DBNL;CORO1C
protein bindingKIF20A;MITD1;PSMC4;PRSS3;OPRD1;ITGB5;ZNF649;HOXA3;HSPB11

SVIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SVIL here. Most of them are supplied by our site. Hope this information will be useful for your research of SVIL.

NEB; Cdk1; Trim69; ZNF16; MYBPC3; LUC7L2; MYO1C; Flot1; CFTR; FLNA; CDK2; MYH9; MYH11; PPP1CC; IQGAP1; CAPZA2

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