TAB2

  • Official Full Name

    TGF-beta activated kinase 1/MAP3K7 binding protein 2

  • Overview

    TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-beta and various pro-inflammatory signals. In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 an

  • Synonyms

    TAB2;TGF-beta activated kinase 1/MAP3K7 binding protein 2;MAP3K7IP2, mitogen activated protein kinase kinase kinase 7 interacting protein 2;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;KIAA0733;TAB-2;TAK1-binding protein 2;TGF-beta-act

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Rhesus macaque
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • E.coli
  • His
  • Non
  • Myc
  • GST
  • Avi
  • Fc

    Involved Pathway

    TAB2 involved in several pathways and played different roles in them. We selected most pathways TAB2 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Leishmaniasis ELK1,H2-AB1,IFNGR1,IL1B,IRAK4,IL12A,HLA-DRB3,FCGR2C,IFNGR2,NCF2
    Osteoclast differentiation IL1A,MAPK11,LILRA1,FCGR1,IFNGR1,NFKBIA,IKBKB,NFATC2,LILRA5,TNF
    Herpes simplex infection CFP,PER3,SRSF7A,H2-AB1,SRPK1,TRP53,TNFB,PVRL1,Ifna11,IFNA7
    Toll-like receptor signaling pathway IL12B,NFKBIAB,MAPK8B,MAPK8A,TLR9,PIK3CD,NFKBIAA,IFNPHI1,IKBKG,CD40
    Epstein-Barr virus infection SKP2,POLR2I,HDAC1,HLA-DRB5,NFKB1,POLR2D,PIK3R5,MDM2,IL10RA,GSK3B
    TNF signaling pathway PTGS2,NFKB1,PIK3CA,CXCL10,CXCL3,ITCH,MAPK10,CREB3L3,CASP7,RELA
    NF-kappa B signaling pathway IKBKB,CCL21B,LTA,LYN,CCL4,TNFRSF11A,TRAF5,GM10591,GADD45B,BCL2A1
    Measles IFNA4,BBC3,STAT5B,TNFRSF10C,TLR9,IRAK1,IFNA12,IFNA13,Fasl,CD209C
    NOD-like receptor signaling pathway MAP3K7,CASP8,TNF,PYCARD,TRAF6,MAPK8B,MAPK12,PYDC1,RIPK2,CARD8

    Protein Function

    TAB2 has several biochemical functions, for example, K63-linked polyubiquitin binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB2 itself. We selected most functions TAB2 had, and list some proteins which have the same functions with TAB2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding EDA2R,KCNA3,Anks6,GOLGA1,SLC19A2,CALML3,ADRB3,C1orf65,EXOSC5,SNTA1
    zinc ion binding PPARAA,FUS,ZDHHC23,TP53,PHF23,BIRC2,IRGF4,PRICKLE2A,APOBEC1,PRICKLE1
    K63-linked polyubiquitin binding TNFAIP3,OTUD7B,SPRTN,ZRANB1B,RNF169,ZRANB3,IKBKG,RNF168,PRPF8,SQSTM1

    Interacting Protein

    TAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAB2.

    TAB1;MAP3K7;BECN1

    Resources

    References

    • van Wijk, SJL; Fiskin, E; et al. Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. NATURE PROTOCOLS 8:1449-1458(2013).
    • Rafferty, BJ; Li, GC; et al. Activation of the alpha 3 Integrin Affects TRAF6 Function In The IL-1 Signaling Pathway of CACO-2 Epithelial Cells. IMMUNOLOGICAL INVESTIGATIONS 39:1-15(2010).

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