TAB2

  • Official Full Name

    TGF-beta activated kinase 1/MAP3K7 binding protein 2

  • Overview

    TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-beta and various pro-inflammatory signals. In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 an

  • Synonyms

    TAB2;TGF-beta activated kinase 1/MAP3K7 binding protein 2;MAP3K7IP2, mitogen activated protein kinase kinase kinase 7 interacting protein 2;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;KIAA0733;TAB-2;TAK1-binding protein 2;TGF-beta-act

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Rhesus macaque
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • E.coli
  • His
  • Non
  • Myc
  • GST
  • Avi
  • Fc

    Involved Pathway

    TAB2 involved in several pathways and played different roles in them. We selected most pathways TAB2 participated on our site, such as MAPK signaling pathway,NF-kappa B signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPKAPK2,RPS6KA4,HSPA6,EGFRA,CACNA1SB,FGF1B,KCNA3,MAP4K1,LAMTOR3,RPS6KA6
    NF-kappa B signaling pathway ICAM1,MYD88,CD40LG,TNFRSF11A,ZAP70,NFKB1,TRAF6,IKBKB,IRAK4,UBE2I
    Measles IRAK1,IFNGR1,PIK3R1,IFNG,OAS1A,FASLG,TYK2,CBLB,MAP3K7,cgr2b
    Epstein-Barr virus infection CDK1,MAP2K7,PSMD1,HLA-DRA,NFKBIB,POLR3K,GSK3B,TBK1,POLR2J,POLR3H
    Herpes simplex infection TTC6,IFNG,IFNA16,SRSF5B,SRSF7,MYD88,TLR2,EIF2AK2,TAP2,Hc
    TNF signaling pathway CXCL1,MAP3K5,IKBKB,VCAM1,CASP8,SOCS3,LIF,BIRC2,MLKL,MMP14
    Leishmaniasis IRAK4,PTPN6,CYBA,ITGB2L,HLA-DRB3,TLR4,HLA-DOA,NCF2,MAPK1,FCGR1A
    NOD-like receptor signaling pathway IKBKG,MAPK3,TNFAIP3,MAPK9,MAPK1,IL8L2,PSTPIP1A,HSP90AA1.1,MAPK12,NFKB1
    Toxoplasmosis IKBKG,SOCS1,Toxoplasma Gondii Microneme Protein MIC3,BIRC7,TNF,NOS2,CD40LG,MAPK11,HLA-DRB4,HLA-DPB1

    Protein Function

    TAB2 has several biochemical functions, for example, K63-linked polyubiquitin binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB2 itself. We selected most functions TAB2 had, and list some proteins which have the same functions with TAB2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ADAM12,NUDCD3,ARL13B,ASCL3,HBZ,PPP4C,PIK3CD,PSIP1,TCP1,DOCK9
    zinc ion binding CAR1,ADH1A,GTF2H2C_2,ZNF212,TRIM50,GCH2,TRIM35-30,TRIM55A,LNX2,USP39
    K63-linked polyubiquitin binding TNFAIP3,OTUD7B,ZRANB1B,ATRIP,SPRTN,ZRANB3,SQSTM1,IKBKG,RNF168,PRPF8

    Interacting Protein

    TAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAB2.

    TAB1;MAP3K7;BECN1

    Resources

    References

    • van Wijk, SJL; Fiskin, E; et al. Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors. NATURE PROTOCOLS 8:1449-1458(2013).
    • Rafferty, BJ; Li, GC; et al. Activation of the alpha 3 Integrin Affects TRAF6 Function In The IL-1 Signaling Pathway of CACO-2 Epithelial Cells. IMMUNOLOGICAL INVESTIGATIONS 39:1-15(2010).

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