TAF1B
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Official Full Name
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
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Background
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. -
Synonyms
TAF1B; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; TATA box binding protein (TBP) associated factor, RNA polymerase I, B, 63kD; TATA box-binding protein-associated factor RNA polymerase I subunit B; RAF1B; RAFI63; SL1; TAFI63; TAF1B TATA box binding protein (TBP) associated factor, RNA polymerase I, B, 63kDa; TATA box binding protein associated factor 1B; TAB1 B; TATA box binding protein associated factor RNA polymerase I subunit B; SL1, 63kD subunit; OTTHUMP00000200348; TBP-associated factor 1B; TATA box-binding protein-associated factor 1B; transcription initiation factor SL1/TIF-IB subunit B; RNA polymerase I-specifi; MGC:9349;
- Involved Pathway
- Protein Function
- Interacting Protein
TAF1B involved in several pathways and played different roles in them. We selected most pathways TAF1B participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, Negative epigenetic regulation of rRNA expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epigenetic regulation of gene expression | EFCAB11;EED;JARID2B;SAP30;MTF2;TET3;SAP130;H3F3B.1;SAP18 |
| Gene Expression | MED6;NR2E3;TYW1;SUDS3;ZNF776;SSRP1A;DDX20;MYBL1;MED7 |
| Negative epigenetic regulation of rRNA expression | SAP30;DNMT1;SIN3B;SUDS3;BAZ2A;TAF1C;TAF1A;SAP30BP;SAP18 |
| NoRC negatively regulates rRNA expression | SUDS3;TAF1D;DNMT3B;SIN3B;SAP30L;TAF1B;SAP130;BAZ2A;EFCAB11 |
| RNA Polymerase I Chain Elongation | TAF1C;CD3EAP;CBX3;CBX3A;TAF1A;TAF1D;EFCAB11;TAF1B;UBTF |
| RNA Polymerase I Promoter Clearance | CD3EAP;EFCAB11;UBTF;TAF1D;MTA3;TAF1B;EHMT2;RRN3;TAF1C |
| RNA Polymerase I Promoter Escape | UBTF;TAF1B;EFCAB11;TAF1C;RRN3;CD3EAP;TAF1D;TAF1A |
| RNA Polymerase I Transcription | MTA3;RRN3;PTRFB;CBX3;GATAD2A;CBX3A;GATAD2AB;TAF1C;CD3EAP |
TAF1B has several biochemical functions, for example, RNA polymerase I CORE element sequence-specific DNA binding, TBP-class protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF1B itself. We selected most functions TAF1B had, and list some proteins which have the same functions with TAF1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase I CORE element sequence-specific DNA binding | PIH1D1;SMARCA4;BAZ2A;TAF1C;TAF1B;EFCAB11;SMARCB1;RRN3 |
| TBP-class protein binding | BRF1;GTF2A1;HHEX;BRF1B;PSMC1;CAND1;PSMC3;THRA;PSMC1A |
| metal ion binding | ZNF771;PFKMA;SP1;TNNI3;ZNF404;ZFP354B;ENOPH1;RBM22;ZNF354B |
| protein binding | SRGAP3;ACMSD;BIN2;FAM168A;GAGE5;TOM1;NCBP1;RAB26;POLH |
| transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting | EFCAB11;TAF1B |
| transcription factor activity, sequence-specific DNA binding | SCAND3;MYT1LA;FOXO3B;ATF2;PPARDB;SFPI1;FOXC1B;PHOX2A;WT1B |
TAF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF1B.
TBP; SET; SRPK1; TAF1C; TAF1A; TAF1D; NAPB; h3_peptide_2-18; POLR1A
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